BƯỚC ĐẦU NGHIÊN CỨU ĐẶC ĐIỂM MỘT SỐ YẾU TỐ NGUY CƠ VÀ BIẾN THỂ GEN Ở NGƯỜI BỆNH HUYẾT KHỐI TĨNH MẠCH NÃO

Abstract

Objectives: To describe some risk factors and genetic variants related to blood coagulation in patients with cerebral venous thrombosis. Methods: A cross-sectional descriptive study was conducted on 54 patients whose ages ≥ 18, were diagnosed with cerebral venous thrombosis by magnetic resonance venography at Bach Mai Hospital and Hanoi Medical University Hospital from June 2022 to July 2023. The Real-time PCR technique was applied to detect some genetic variants associated with cerebral venous thrombosis. Results: The average age was 43.76 ± 12.376; the average age of the male group was 8 years older than that of the female group; the male/female ratio was equal. Lupus anticoagulant, hyperhomocysteinaemia, and oral contraceptive drugs were risk factors accounting for the highest percentages of 24.1%, 22.7%, and 20.4%, respectively. Mutations in the factor V Leiden and factor II G20210A genes were unrecorded. while mutations in the MTHFR C677T and A1298C genes were 31.5% and 40.7%, respectively. Conclusion: This study provides important information on risk factors and the prevalence of gene variants related to blood coagulation in patients with cerebral venous thrombosis. To better understand the characteristics of risk factors in the Vietnamese population, more extensive studies are required.