NGHIÊN CỨU BÀO CHẾ NANO POLYMER CHỨA CURCUMIN BẰNG PHƯƠNG PHÁP NHŨ HOÁ BỐC HƠI DUNG MÔI

Abstract

Objectives: To prepare the curcumin-loaded polymeric nanoparticles. Methods: Preparation of curcumin-loaded polymeric nanoparticles using emulsification solvent evaporation technique, solidification by spray drying method, and evaluation of some physicochemical properties of prepared curcumin-loaded polymeric nanoparticles. Results: The formulation of curcumin-loaded polymeric nanoparticles was chosen, including the type of polymer was Eudragit RS100 (with the Eudragit/Curcumin ratio was 1/1 (w/w)); Tween 80 was chosen as the surfactant with the concentration at 2% in water; internal phase/external phase ratio was 3/20 (v/v). Some in-processing parameters were investigated and selected, including the emulsifying stirring speed at 800 r.p.m for 5 minutes, homogenization stirring speed at 6000 r.p.m for 10 minutes, and solvent evaporation time for 3 hours. The prepared curcumin-loaded polymeric nanoparticle suspensions were solidified using the spray drying method to obtain a yellow, dry, and homogenous powder; the moisture content was 2.38 ± 0.01%; the curcumin content was 9.39 ± 0.1 mg/g. After re-dispersing in water, the particle size was 102.4 ± 1.04 nm, the polydispersity index was 0.45 ± 0.04, and the Zeta potential was 4.6 ± 0.34; the in-vitro dissolution test of curcumin released from polymeric nanoparticles was 85.41% at 10^th minute, and the solubility of curcumin from polymeric nanoparticle was 582.7 ± 21.9 µg/mL. Conclusion: The study prepared and evaluated some physicochemical properties of curcumin-loaded polymeric nanoparticles.