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Date Published: 28/08/2024
Abstract Views: 33
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DOI: https://doi.org/10.56535/jmpm.v49i6.743
Issue
Vol. 49 No. 6 (2024): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 6 - 2024
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Articles
How to Cite
Tran, H. N., Tran, D. T., Nguyen, A. Q., Vy, X. T., & Trinh, V. D. (2024). VMMU75_EVALUATION OF SUGAMMADEX EFFICACY FOR REVERSAL OF NEUROMUSCULAR BLOCK IN PATIENTS UNDERGOING SPINAL FIXATION SURGERY_Tran Hoai Nam. Journal of Military Pharmaco-medicine, 49(6), 143-153. https://doi.org/10.56535/jmpm.v49i6.743

VMMU75_EVALUATION OF SUGAMMADEX EFFICACY FOR REVERSAL OF NEUROMUSCULAR BLOCK IN PATIENTS UNDERGOING SPINAL FIXATION SURGERY_Tran Hoai Nam

Hoai Nam Tran1, Dac Tiep Tran1, Anh Quan Nguyen1, Xuan Thang Vy1, , Van Duc Trinh2
1 Bệnh viện Quân y 103, Học viện Quân y
2 Bộ môn- Khoa Gây mê, Bệnh viện Quân y 103

Main Article Content

Abstract

Objectives: To evaluate sugammadex efficacy for reversal of neuromuscular block in patients undergoing spinal fixation surgery. Methods: A prospective clinical intervention study with comparisons was conducted in 66 patients undergoing spinal fixation surgery with total anesthesia using rocuronium and neuromuscular blockade was reversed randomly by using sugammdex 2mg/kg ( S group n=33) or neostigmine 50mcg/kg và atropine 10mcg/kg (N group n=33). The tracheal tube was extubated in the operating room. Results: After injecting neuromuscular blockade reversal drugs, the mean time for recovery of  the TOF(Train-of-four) ratio to 0.7, 0.8 and 0.9 was 1.83 ± 0.49 minutes; 2.29 ± 0.62 minutes; 2.73 ± 0.73 minutes (S group) and 7.3 ± 1.24 minutes ; 9.22 ± 1.79 minutes ; 11.71 ± 2.45 minutes (N group). The mean time to extubation was 3.91 ± 1.08 minutes (S group) and 14.07 ± 2.88 minutes (N group). The number of patients with bradycardia, increased salivation and dry mouth in the sugammadex group was significantly less than in the neostigmine group. Conclusion: In patients who underwent spinal fixation surgery, sugammadex 2 mg/ kg effectively and safely reversed rocuronium inducing neuromuscular blockade and its side effects were mild and transient.

Article Details

Keywords

sugammadex, muscle relaxation reversal, spinal fixation.

References

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