KẾT QUẢ ĐIỀU TRỊ VIÊM TỤY CẤP DO TĂNG TRIGLYCERIDE

Bá Thành Lại1, Hồ Chí Thanh , Nguyễn Huy Thông
1 Bệnh viện Quân y 103, Học viện Quân y

Main Article Content

Abstract

Summary:


Background: Treatment for hypertriglyceridemia-induced acute pancreatitis, in addition to emergency treatment methods such as conventional acute pancreatitis, requires methods to lower blood triglycerides.


Aim: Evaluate the outcome of treatment for hypertriglyceridemia-induced acute pancreatitis.


Objects and methods: Study of 95  patients of hypertriglyceridemia induced acute pancreatitis at Military Hospital 103 from January 2021 to October 2023. Patients were randomized into two groups: the intravenous insulin hypotriglyceridemia (ITTM) group and the plasma exchange (PEX) group. Data processing was done with SPSS 22.0 software.


Results: The PEX group was 22.1%; the intravenous insulin group was 77.89%. Other measures include: respiratory resuscitation was 6.31%, cardiovascular resuscitation was 7.36%, abdominal fluid drainage was 66.31%, surgery was 5.26%. The average treatment day was 9.7 ± 6.67 days, complications was 8.42%. The treatment of good results was 62.10%, medium was 34.74% and poor was 3.16%. Comparison of triglyceride lowering results between the two groups PEX and ITTM were the same with p > 0.05, the treatment results between the two groups ware not different with p > 0.05.


Conclusions:


Treatment of acute pancreatitis due to increased triglyceride with intravenous insulin infusion is safe and gives similar results to plasma conversion, but a large sample size study is needed to evaluate the effectiveness of the method.

Article Details

References

1. Garg R and Rustagi T, Management of Hypertriglyceridemia Induced Acute Pancreatitis. BioMed Research International. 2018; 4721357:1-12.
2. Yang AL and McNabb-Baltar J. Hypertriglyceridemia and acute pancreatitis. Pancreatology. 2020; 20(5):795-800.
3. Leppäniemi A, Tolonen M, Tarasconi A, et al. 2019 WSES guidelines for the management of severe acute pancreatitis. World J Emerg Surg. 2019; 14:27.
4. Song X, Shi D, Cui Q et al. Intensive insulin therapy versus plasmapheresis in the management of hypertriglyceridemia-induced acute pancreatitis (Bi-TPAI trial): Study protocol for a randomized controlled trial. Trials. 2019; 20(365):1-5.
5. Yu S, Yao D, Liang X, et al. Effects of different triglyceride-lowering therapies in patients with hypertriglyceridemia-induced acute pancreatitis. Experimental and Therapeutic Medicine. 2020; 19:2427-2432.
6. Banks PA, et al. Classification of acute pancreatitis - 2012: Revision of the Atlanta classification and definitions by international consensus. Gut. 2013; 62(1): 102-111.
7. Tamez-Pérez HE, Sáenz-Gallegos R, et al. Insulin therapy in patients with severe hypertriglyceridemia. Rev Med Inst Mex Seguro Soc. 2006; 44(3):235-7.
8. Navina S, Chathur Acharya C, DeLany JP, et al. Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. Sci Transl Med. 2011; 3(107):1-26.
9. Jin M, Peng JM, Zhu HD, et al. Continuous intravenous infusion of insulin and heparin vs plasma exchange in hypertriglyceridemia-induced acute pancreatitis. J Dig Dis. 2018; 19(12): 766-772.
10. Nguyễn Gia Bình và CS. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và điều trị viêm tụy cấp tăng triglyceride. Bệnh viện Bạch Mai. 2013; Bộ Y tế.
11. Asencio CM, and Fleiszig ZB. Intra-abdominal hypertension: A systemic complication of severe acute pancreatitis. Medicina. 2022; 58(785):1-10.
12. Malbrain ML, De Laet IE, et al. Intraabdominal hypertension: Definitions, monitoring, interpretation and management. Best pract res clin anaesthesiol. 2013; 27(2):249-270.