NGHIÊN CỨU ĐỘC TÍNH CẤP VÀ TÁC DỤNG HẠ LIPID MÁU NỘI SINH CỦA CAO KHÔ LÁ CÂY TRÀ HOA VÀNG (CAMELLIA HAKODAE NINH) TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Objectives: To examine the acute toxicity and evaluate the endogenous hypolipidemic effect of dry extracts from yellow tea leaves Camellia hakodae Ninh (CKL-THV) in experimental mice. Methods: The acute toxicity in mice was examined using the Litchfield-Wilcoxon method; the endogenous hypolipidemic effect in mice with endogenous dyslipidemia induced by P-407 was evaluated using the method of Millar et al.. Results: Mice using CKL-THV still ate, acted, and excreted normally. No mouse died within 72 hours after taking CKL-THV. The results of lipid indices showed that the CKL-THV at doses of 0.6 g/kg and 1.8 g/kg reduced TC (26.5% and 28.3%), TG (21.2% and 17.3%), and non HDL-C (31.1% and 33.8%) compared to those of the pathological group (p < 0.01). Conclusion: CKL-THV did not cause acute toxicity in mice; LD50 was not identified. CKL-THV had an effect on reducing TC, TG, and non HDL-C in the model of endogenous dyslipidemia.