ĐÁNH GIÁ TÁC DỤNG CHỐNG VIÊM VÀ HẠ ACID URIC MÁU CỦA VIÊN NANG CỨNG ĐỊNH THỐNG PHONG TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Objectives: To evaluate the anti-inflammatory effect and anti-hyperuricemic activity of Dinh Thong Phong capsules in experimental animals. Methods: The anti-inflammatory activity was evaluated by the carrageenan-induced paw edema test in rats. The anti-hyperuricemic activity was evaluated by the potassium oxonate-induced hyperuricemic model in mice. Results: Anti-inflammatory effect: The percentage increase in paw edema of the ĐTP groups at the doses of 500 mg/kg and 1,500 mg/kg was significantly lower than that of the control group. The percentage inhibition of paw edema of the ĐTP 500 mg/kg group ranged from 2.20 to 6.49%; that of the ĐTP 1,500 mg/kg group ranged from 6.23 to 12.63%. Anti-hyperuricemic activity: The blood uric acid levels of the ĐTP group at the doses of 860 mg/kg and 2,580 mg/kg were 79.50 ± 12.80 and 78.40 ± 21.50 µmol/L, respectively, significantly lower compared to the model group (126.30 ± 52.88 µmol/L) (p = 0.001). There were no significant differences (p > 0.05) in blood uric acid levels between the ĐTP groups and the positive control group. Conclusion: ĐTP capsules showed an anti-inflammatory effect in the carrageenan-induced paw edema test in rats and had anti-hyperuricemic activity in the potassium oxonate-induced hyperuricemic model in mice.