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Date Published: 27/10/2023
Abstract Views: 88
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DOI: https://doi.org/10.56535/jmpm.v48i8.457
Issue
Vol. 48 No. 8 (2023): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 8 - 2023
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Articles
How to Cite
Nguyen, Q. H., Đỗ, N. S., & Nguyễn, T. K. (2023). MORTALITY PROGNOSIS VALUE OF THE SERUM GFAP CONCENTRATION IN SEVERE TRAUMATIC BRAIN INJURY PATIENTS. Journal of Military Pharmaco-medicine, 48(8), 110-119. https://doi.org/10.56535/jmpm.v48i8.457

MORTALITY PROGNOSIS VALUE OF THE SERUM GFAP CONCENTRATION IN SEVERE TRAUMATIC BRAIN INJURY PATIENTS

Quang Huy Nguyen , Ngọc Sơn Đỗ, Trung Kiên Nguyễn

Main Article Content

Abstract

Objectives: To determine the mortality prognosis of serum GFAP concentration in severe traumatic brain injury (TBI) patients. Methods: A prospective, cohort study on 56 patients diagnosed with severe traumatic brain injury. Patients were treated by a hospital’s protocol, blood samples were taken at 6, 12, 24, 48, and 72 hours after admission, respectively and assessed the outcome after 28 days of admission. Blood samples were stored cryopreserved (-80°C) until used, and analysis of GFAP concentrations was performed by using the MyBiosource ELISA KIT. Data according to research medical records, were coded and processed according to statistical methods. Results: Serum GFAP concentrations in the death group were significantly statistically higher than the survival group’ results at all times. Serum GFAP concentrations in T1, T2, T3, T4, and T5 times had good AUC value in mortality prognosis. In T3 time, it had the biggest AUC (0.832), cutoff point 76.724 pg/mL with Se 63.6% và Sp 88.5%. Conclusion: Serum GFAP concentrations in the 6, 12, 24, 48, and 72 hours after hospital admission in severe traumatic brain injury patients had significant statistics in mortality prognosis with good AUC. 24 hours after admission, serum GFAP concentration had the biggest AUC (0.832) in mortality prognosis with cutoff 76.724 pg/mL, Se 76.9% and Sp 87.9%.

Article Details

Keywords

Severe traumatic brain injury, Biomarker, GFAP

References

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