CLINICAL AND PARACLINICAL CHARACTERISTICS OF ACUTE PANCREATITIS WITH HYPERTRIGLYCERIDEMIA

Hồ Chí Thanh , Bounthong Inkhamphanh , Nguyễn Huy Thông

Main Article Content

Abstract

Objectives: To describe clinical and paraclinical characteristics of acute pancreatitis with hypertriglyceridemia and related factors. Methods: A prospective, cross-sectional descriptive study was conducted on 72 acute pancreatitis patients with hypertriglyceridemia at Military Hospital 103 from January 2021 to May 2023. The examination, diagnosis, and treatment procedures were performed consistently according to the guidelines of the World Society of Emergency Surgery (WSES) 2019.  Results: The average age was 42.8 ± 10.84, the percentage of men accounted for the highest figure (80.6%), and the occupation of civil servants was 47.2%. The abdominal pain was 97.2%, nausea was 76.4%, and excessive use of alcohol was 62.5%. The mean blood amylase was 675.1 ± 191.72 U/L, and the mean blood triglyceride was 19.54 ± 16.54 mmol/L. Severe acute pancreatitis was 22.2%, and blood triglyceride levels were unrelated to disease severity with p > 0.05. Conclusion: Acute pancreatitis with hypertriglyceridemia was more common in men with a history of alcohol abuse. Clinical symptoms were mainly abdominal pain, vomiting, abdominal distension, and dyspnea. Triglyceride levels were not related to disease severity.     

Article Details

References

1. Peery AF, Crockett SD, Murphy C. et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: Update 2021. Gastroenterology. 2022; 162(2): 621-644.
2. Nguyễn Khánh Trạch và Trần Ngọc Ân. Viêm tụy cấp, Bệnh học nội khoa - Dành cho đối tượng sau đại học. Nhà xuất bản Y học, Hà Nội. 2004.
3. Zhu Y, Pan X, Zeng H, et al. A Study on the etiology, severity, and mortality of 3260 patients with acute pancreatitis according to the revised atlanta classification in jiangxi china over an 8-year period. Pancreas. 2017, 46(4):504-509.
4. Fortson MR, Freedman SN and Webster PD 3rd. Clinical assessment of hyperlipidemic pancreatitis. Am J Gastroenterol. 1995; 90(12):2134-9.
5. Yadav D, and Pitchumoni CS. Issues in hyperlipidemic pancreatitis. J Clin Gastroenterol. 2003, 36(1):54-62.
6. Nguyễn Gia Bình. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và điều trị viêm tụy cấp tăng triglyceride. Bệnh viện Bạch Mai. Bộ Y tế. 2013.
7. Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis-2012: Revision of the Atlanta classification and definitions by international consensus. Gut. 2013, 62(1):102-111.
8. Leppäniemi A, Tolonen M, Tarasconi A, et al. 2019 WSES guidelines for the management of severe acute pancreatitis. World J Emerg Surg. 2019:14-27.
9. James TW, and Crockett SD. Management of acute pancreatitis in the first 72 hours. Curr Opin Gastroenterol. 2018; 34(5):330-335.
10. Lee SH, and Park JM. Hypertriglyceridemia is a risk factor for fever in early acute non-biliary pancreatitis. 2021; 78(6):337-343.
11. Yang AL, and McNabb-Baltar J. Hypertriglyceridemia and acute pancreatitis. Pancreatology. 2020; 20(5):795-800.
12. Sun Y, and Jin J. Risk factors for recurrent pancreatitis after first episode of acute pancreatitis. 2022; 15:1319-1328.