Article Sidebar
Views PDF: 40
Study on Changes in Clinical Features, Respiratory Function, and Plasma Cytokine Concentrations in Chronic Obstructive Pulmonary Disease Patients Treated with Inhaled Supernatant Solutions from Human Mesenchymal Stem Cell Culture Medium
Main Article Content
Abstract
Study on Changes in Clinical Features, Respiratory Function, and Plasma Cytokine Concentrations in Chronic Obstructive Pulmonary Disease Patients Treated with Inhaled Supernatant Solutions from Human Mesenchymal Stem Cell Culture Medium
Abstract
Objective: The objective of this study was to determine the changes in exercise capacity, respiratory function, and the levels of certain cytokines in the serum of patients with Chronic Obstructive Pulmonary Disease (COPD) before and after treatment with topically applied stem cell culture medium derived from human mesenchymal stem cells.
Subjects and Methods: The study involved 30 stable COPD patients treated with topically applied stem cell culture medium derived from human mesenchymal stem cells in a regimen of 4 sessions, each with a dosage of 9ml per session, spaced 7 days apart. The study was conducted from August 2021 to November 2023 at BVQY175. The evaluation of changes in clinical characteristics, respiratory function, and serum cytokine levels was conducted before treatment and at the end of the 3-month treatment period.
Results: The study assessing the effectiveness of topically applied stem cell culture medium derived from human mesenchymal stem cells in treating 30 COPD patients demonstrated significant improvement in clinical symptoms and respiratory function. However, no significant changes were observed in the levels of cytokines before and after the 3-month treatment period. No adverse side effects were recorded during the treatment process.
Article Details
Keywords
; Tế bào gốc; Bệnh phổi tắc nghẽn mạn tính; Cytokines, Stemsup; Stem Cells; Chronic Obstructive Pulmonary Disease; Cytokines
References
2. Lê Thị Bích Phượng, Đỗ Quyết, Lê Văn Đông và CS. Nghiên cứu sự thay đổi nồng độ một số cytokine trong huyết tương của bệnh nhân bệnh phổi tắc nghẽn mạn tính được điều trị bằng ghép tế bào gốc trung mô đồng loại từ mô dây rốn. Tạp chí Y học Việt Nam. 2021; 509(2).
3. Terunuma A, Yoshioka Y, Sekine T, et al. Extracellular vesicles from mesenchymal stem cells of dental pulp and adipose tissue display distinct transcriptomic characteristics suggestive of potential therapeutic targets. J Stem Cells Regen Med. 2021; 17(2):56-60.
4. Barnes PJ. The cytokine network in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2009; 41(6):631-638.
5. Nguyễn Hải Công. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và yếu tố tiên lượng tử vong ở bệnh nhân đợt cấp bệnh phổi tắc nghẽn mạn tính nhập viện. Luận án Tiến sĩ Y khoa. Học viện Quân y. 2021.
6. Delieva A, Dolinina L, and Trofimov V. The level of anti-inflammatory cytokine IL-10 in patients with chronic obstructive pulmonary disease of varying severity. Eur Respir J. 2013; 42(57).
7. Zou Y, Chen X, Liu J, et al. Serum IL-1β and IL-17 levels in patients with BPTNMT: associations with clinical parameters. Int J Chron Obstruct Pulmon Dis. 2017; 12:1247-1254.
8. Chiş AF, Soritau O, Catana A, et al. VEGF serum levels in BPTNMT patients without pulmonary hypertension - a case control study. Eur Respir J. 2018; 52(62).
9. Farid Hosseini R, Jabbari Azad F, Yousefzadeh H, et al. Serum levels of vascular endothelial growth factor in chronic obstructive pulmonary disease. Med J Islam Repub Iran. 2014; 28(85).
10. Tejwani V. Airway and systemic prostaglandin e2 association with bptnmt symptoms and macrophage phenotype. Chronic Obstr Pulm Dis BPTNMT Found. 2023; 10(2):159-169.
11. Wu M, Han ZB, Liu JF, Wang YW, et al. Serum-free media and the immunoregulatory properties of mesenchymal stem cells in vivo and in vitro. Cell Physiol Biochem. 2014; 33(3):569-580.
12. Devaney J, Horie S, Masterson C, et al. Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E, coli in the rat. Thorax. 2015; 70(7):625-635.