ĐÁNH GIÁ MỐI LIÊN QUAN GIỮA TỶ LỆ NHIỄM HPV VÀ KẾT QUẢ TẾ BÀO HỌC Ở PHỤ NỮ KHÁM SÀNG LỌC UNG THƯ CỔ TỬ CUNG TẠI MỘT SỐ BỆNH VIỆN KHU VỰC HÀ NỘI NĂM 2022 - 2023

Abstract

Objectives: To determine the relationship between the prevalence of HPV genotypes and abnormal cervical cytology results in women undergoing cervical cancer screening. Methods: A cross-sectional descriptive study was conducted on 106 women undergoing screening at the Hanoi University Medical Hospital and the Military Medical Academy. These women exhibited abnormal cervical cytology results. Genotyping of the HPV gene was performed using Multiplex-PCR and Nested-PCR methods. Results: Among the 106 research subjects, 104 cases (98.1%) had cervical cell abnormalities, the most common being cervical intraepithelial neoplasia (CIN). When determining the HPV genotypes, we obtained 77 out of 106 positive results for HPV, with 66 cases positive for at least one HPV genotype. Of the 77 positive results, 60 cases (77.9%) were positive for high-risk HPV types, with HPV 16 being the most commonly detected type. Two cases were clinically diagnosed with squamous cell carcinoma (SCC) of the cervix and were positive for HPV 18 and HPV 11, respectively. We also detected 10 cases positive for HPV genotypes that were not included in the types surveyed. Conclusion: HPV 16 is the most prevalent genotype in samples of abnormal cervical cytology. Additionally, genotypes 18 and 11 were found in patients clinically diagnosed with SCC.