SO SÁNH SỰ THAY ĐỔI NỒNG ĐỘ LACTATE MÁU GIỮA NHÓM SỐNG VÀ TỬ VONG Ở BỆNH NHÂN SUY ĐA TẠNG

Abstract

Objectives: To survey and compare changes in arterial blood lactate levels between survival and dead groups in patients with multi-organ failure. Methods: A descriptive, prospective, longitudinal study on 40 patients who werevadmitted to the Internal Resuscitation Department, Military Hospital 103 and were diagnosed with multiple organ failure were included in the study. Multiple organ dysfunction syndrome (MODS) was evaluated according to the SOFA (sequential organ failure assessment) score, with a SOFA score ≥ 3 or an increase of ≥ 1 point compared with admission to the ICU and MODS was diagnosed when ≥ 2 organ failure persisted for more than 24 hours. Comparison of blood lactate levels between survival and death groups at the time of the study (T₀, T₁, T₂, T₃, T₄, T₅). Results: The study included 40 patients, males accounted for 60% and the mean age was 63.2 ± 15.9. The proportion of patients with lactate > 4 mmol/L was the highest, followed by lactate 2 - 4 mmol/L, and lactate < 2 mmol/L was the lowest at all time points. In the group of patients who died, lactate concentration increased at the time of diagnosis and peaked at 6 hours after diagnosis, and then gradually decreased. At the time of T_c values of lactate ranged from 2 - 4, and lactate > 4 in the death group was statistically significantly higher than that in the survival group (p < 0.05). Conclusion: In the group of patients who died, blood lactate levels increased at the time of diagnosis of multiple organ failure (T₀), continued to increase to the highest figure after     6 hours (T₁), and were statistically significantly higher than in the group of patients who survived (p < 0.05) at all study time points.