SỰ THAY ĐỔI NỒNG ĐỘ ANGIOPOIETIN-1 VÀ ANGIOPOIETIN-2 Ở BỆNH NHÂN NHIỄM KHUẨN HUYẾT TẠI BỆNH VIỆN HỮU NGHỊ VIỆT TIỆP GIAI ĐOẠN 2018 - 2020

Abstract

Objectives: To analyze the change in angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) levels in patients with sepsis. Methods: A prospective study was conducted on 105 sepsis patients at Viet Tiep Hospital in 2018 - 2020. Results: The mean age of patients with sepsis without septic shock was 65.8 ± 17.8, and with septic shock was 66.5 ± 14.9. The creatinine, pro-calcitonin, lactate indexes in the septic shock were higher than those in the sepsis. The levels (median, interquartile range) of Ang-1 of the sepsis and septic shock were 307.4 (79.5 - 946.1 pg/mL) and 172.4 (32.4 - 590.1 pg/mL), respectively. The median (interquartile range) of Ang-2 in the sepsis and septic shock were 515.6 (341.4 - 747.3 pg/mL) and 1096,8 (797.4 - 1291.3 pg/mL), respectively. The level of Ang-1 at the time of diagnosis, three days, and seven days after were: 187.1 (55.1 - 759.4 pg/mL), 390.8 (136.3 - 1290.1 pg/mL), and 833.5 (356.8 - 1580.7 pg/mL) respectively. Meanwhile, the concentrations of Ang-2 at these times were: 785.5 (402.9 - 1162.8). 521.9 (254.1 - 792.3) and 353.5 (232.0 - 531.8 pg/mL). Conclusion: The level of Ang-1 in the sepsis was higher than in the septic shock; Ang-2 concentration in the sepsis group was lower than that in the septic shock group; The Ang-1/Ang-2 ratio gradually increased from the time of diagnosis of sepsis to 3 days and seven days after diagnosis.