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Date Published: 28/04/2023
Abstract Views: 84
Views PDF: 58
DOI: https://doi.org/10.56535/jmpm.v48i4.253
Issue
Vol. 48 No. 4 (2023): JOURNAL OF MILITARY PHARMACO-MEDICINE 4-2023
Section
Articles
How to Cite
Le, T. D., Luu, T. B., & Nguyen, M. N. (2023). EFFICACY OF PLATELET-RICH PLASMA INTRA-ARTICULAR INJECTION IN ADJUNCTION TO CONVENTIONAL THERAPY FOR ASEPTIC NECROSIS OF FEMORAL HEAD. Journal of Military Pharmaco-medicine, 48(4), 160-171. https://doi.org/10.56535/jmpm.v48i4.253

EFFICACY OF PLATELET-RICH PLASMA INTRA-ARTICULAR INJECTION IN ADJUNCTION TO CONVENTIONAL THERAPY FOR ASEPTIC NECROSIS OF FEMORAL HEAD

Thuy Duong Le1, , Luu Thi Binh2, Nguyen Minh Nui3
1 Hai Phong Medical College
2 Thai Nguyen Province Health Department
3 Vietnam Military Medical University

Main Article Content

Abstract

Objectives: To evaluate the results of autologous platelet-rich plasma (PRP) intra-articular injection combined with medical therapy in treating aseptic necrosis of the femoral head (ANFH) after 5 months. Subjects and methods: Non-control interventional study, comparing before and after treatment for 30 patients (47 sterile necrotic femoral heads) who received 2 injections of PRP one month apart. Evaluation of clinical symptoms and images of necrosis on magnetic resonance imaging of the hip joint after 5 months. Results: The mean Visual Analogue Scale (VAS) decreased from 7.03 ± 1.90 to 3.77 ± 2.64, and the rate of severe pain decreased from 63.3% to 23.3%. The average range of motion of the hip joint increased (flexion from 87.17 ± 13.69 to 101.50 ± 14.69; abduction from 21.50 ± 5.89 to 28.50 ± 7.09; external rotation from 28.33 ± 4.01 to 34.00 ± 5.15; internal rotation from 30.33 ± 4.90 to 34.17 ± 4.93 degrees) with p < 0.001. According to Merle D'Aubigné, the ability to walk score increased from 4.05 ± 0.83 to 4.95 ± 0.76 (p < 0.001). Magnetic resonance imaging showed the rate of bone marrow edema decreased from 66.7% to 40.0% (p < 0.05), four sterile necrotic femoral heads from stage III to stage IV. Conclusion: The results of autologous PRP intra-articular injection combined with medical therapy in treating ANFH have markedly improved analgesia and motor function.

Article Details

Author Biographies

Luu Thi Binh, Thai Nguyen Province Health Department

 

Formerly Head of Musculoskeletal Department, Thai Nguyen National Hospital; Lecturer in Department of Internal Medicine,Thai Nguyen University of Medicine and Pharmacy. Currently Deputy Director of Thai Nguyen Department of Health

 

Nguyen Minh Nui, Vietnam Military Medical University

Deputy Head of the Department of Rheumatology and Endocrinology, VietNam Military Medical University

Keywords

Aseptic necrosis of the femoral head, Platelet-rich plasma

References

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