TỶ LỆ RỐI LOẠN CHỨC NĂNG TIỂU CẦU VÀ MỐI LIÊN QUAN VỚI BIẾN CỐ HUYẾT KHỐI Ở BỆNH NHÂN OXY HÓA MÁU QUA MÀNG NGOÀI CƠ THỂ

Abstract

Objectives: To determine the prevalence of platelet dysfunction and examine its association with thrombotic events in patients undergoing extracorporeal membrane oxygenation (ECMO). Methods: A single-center prospective cohort study was conducted on 54 ECMO patients aged ≥ 16 years at Cho Ray Hospital from March 2023 to March 2026. ECMO patients were enrolled, and platelet function was assessed using the PFA-200 (measuring Col/Epi and Col/ADP closure times) at four time points: before ECMO initiation (T0), at 24 hours (T1), 72 hours after ECMO initiation (T2), and 12 - 24 hours post-decannulation (T3). Results: Among the patients included in the study, thrombotic events occurred in 25 patients (46.3%). The overall rates of platelet dysfunction at T0, T1, T2 and T3 were 38.9%, 98.1%, 98.1% and 44.4%, respectively. Col/Epi and Col/ADP values increased during ECMO and decreased after ECMO decannulation. However, no statistically significant differences in Col/Epi or Col/ADP were observed between patients with and without thrombotic events across all the assessed time points. Conclusion: Platelet dysfunction is highly prevalent during ECMO support and decreases following decannulation. However, this study found no statistically significant association between platelet dysfunction and thrombotic events.