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Issue: Vol. 51 No. 7 (2026): JOURNAL OF MILITARY PHARMACO-MEDICINE No.7 - 2026
Section: Articles
DOI: 10.56535/jmpm.v51i7.2114
Date Published: 28/07/2026
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Nguyen, V. T., Nguyen, T. T., & Nguyen, T. T. H. (2026). PLASMA β2-MICROGLOBULIN REDUCTION EFFECTIVENESS FOLLOWING HDF-ONLINE IN MAINTENANCE HEMODIALYSIS PATIENTS AT MILITARY HOSPITAL 103. Journal of Military Pharmaco-medicine, 51(7), 170-178. https://doi.org/10.56535/jmpm.v51i7.2114

PLASMA β2-MICROGLOBULIN REDUCTION EFFECTIVENESS FOLLOWING HDF-ONLINE IN MAINTENANCE HEMODIALYSIS PATIENTS AT MILITARY HOSPITAL 103

Van Tuyen Nguyen1, Thi Trang Nguyen1,2, Thi Thu Ha Nguyen1,2,
1 Vietnam Military Medical University
2 Military Hospital 103

Main Article Content

Abstract

Objectives: To evaluate the effectiveness of HDF-online (online hemodiafiltration) in reducing plasma β2-microglobulin (β2M) levels in maintenance hemodialysis (MHD) patients. Methods: A descriptive cross-sectional study with a pre–post comparison within the same patients was conductedon 67 MHD patients at the Nephrology and Dialysis Department, Military Hospital 103 from July 2025 to April 2026. β2M was quantified at two time points: Before and immediately after HDF-online. Results: Plasma β2M concentrations decreased significantly from a median of 27.41 mg/L (IQR: 24.98 - 29.51) to 10.68 mg/L (IQR: 8.59 - 12.60), with a mean absolute decrease of 16.86 ± 4.54 mg/L and a mean percentage decrease of 60.86 ± 10.44%. β2M reduction rate was higher in the group with Kt/V ≥ 1.4, albumin ≥ 38 g/L, preserved urine output, without diabetes mellitus, and dialysis vintage < 5 years. Conclusion: HDF-online significantly reduced β2M levels in MHD patients. The β2M reduction ratio (β2M-RR) was associated with Kt/V, serum albumin, residual urine output, diabetes mellitus, and dialysis vintage.

Keywords

Maintenance hemodialysis, HDF-online, β2-microglobulin

Article Details

References

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