ASSOCIATION BETWEEN PREOPERATIVE SERUM PROTEIN AND ALBUMIN LEVELS AND EARLY POSTOPERATIVE COMPLICATIONS FOLLOWING THORACOSCOPIC ESOPHAGECTOMY FOR ESOPHAGEAL CANCER
Main Article Content
Abstract
Objectives: To evaluate the association between preoperative serum albumin and total protein levels and early postoperative complications following thoracoscopic esophagectomy for esophageal cancer. Methods: A retrospective, descriptive study was conducted on 108 patients with esophageal cancer who underwent thoracoscopic esophagectomy at Military Hospital 103 between March 2019 and December 2025. Results: The mean preoperative serum albumin level was 40.5 ± 3.7 g/L, and the mean total serum protein level was 73.4 ± 5.3 g/L. The overall rate of early postoperative complications was 24.1% (26/108 patients). Respiratory complications were the most common (15.7%), followed by anastomotic leakage (6.5%), chylothorax (2.8%), and postoperative mortality (1.9%). No statistically significant differences in the incidence of early postoperative complications were observed between patient groups stratified according to preoperative serum albumin and protein levels (p > 0.05). In multivariable logistic regression analysis, preoperative serum albumin and total protein were not identified as independent predictors of early postoperative complications. Conclusion: Preoperative serum albumin and total protein levels were not significantly associated with early postoperative complications following thoracoscopic esophagectomy for esophageal cancer.
Keywords
Esophageal cancer, Thoracoscopic esophagectomy, Esophagectomy
Article Details
References
2. Zhou C, Ma G, Li X, et al. Is minimally invasive esophagectomy effective for preventing anastomotic leakages after esophagectomy for cancer? A systematic review and meta-analysis. World J Surg Oncol. 2015; 13:269.
3. Velotta JB, Seder CW, Bonnell LN, et al. 2024 Update of the society of thoracic surgeons short-term esophagectomy risk model: More inclusive and improved calibration. Ann Thorac Surg. 2024; 118(4):834-842.
4. Fabbi M, Hagens ERC, van Berge Henegouwen MI, and Gisbertz SS. Anastomotic leakage after esophagectomy for esophageal cancer: Definitions, diagnostics, and treatment. Dis Esophagus. 2021; 34(1).
5. Tabatabai A, Hashemi M, Mohajeri G, et al. Incidence and risk factors predisposing anastomotic leak after transhiatal esophagectomy. Ann Thorac Med. 2009; 4(4):197-200.
6. van Kooten RT, Voeten DM, Steyerberg EW, et al. Patient-related prognostic factors for anastomotic leakage, major complications, and short-term mortality following esophagectomy for cancer: A systematic review and meta-analyses. Ann Surg Oncol. 2022; 29(2):1358-1373.
7. Goh S L, De Silva R P, Dhital K, and Gett R M. Is low serum albumin associated with postoperative complications in patients undergoing oesophagectomy for oesophageal malignancies?. Interact Cardiovasc Thorac Surg. 2015; 20(1): 107-113.
8. Li R and Zhu Y. Preoperative hypoalbuminemia is associated with higher 30-day mortality and complications after esophagectomy. Am Surg. 2025; 91(1):51-58.
9. Sugimoto A, Toyokawa T, Miki Y, et al. Preoperative c-reactive protein to albumin ratio predicts anastomotic leakage after esophagectomy for thoracic esophageal cancer: A single-center retrospective cohort study. BMC Surg. 2021; 21(1): 348.
10. Ryan A M, Hearty A, Prichard R S, et al. Association of hypoalbuminemia on the first postoperative day and complications following esophagectomy. J Gastrointest Surg. 2007; 11(10):1355-1360.