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NGHIÊN CỨU BÀO CHẾ TIỂU PHÂN NANO POLYMER ANDROGRAPHOLID BẰNG PHƯƠNG PHÁP NHŨ HÓA BỐC HƠI DUNG MÔI
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Abstract
Objects: The present study was conducted to prepare andrographolide polymeric nanoparticles and evaluation of some properties and quality criteria of the prepared nanoparticles.
Methods: The formulation of andrographolide polymeric nanoparticles was prepared by using emulsification-evaporation technique. Prepared andrographolide polymeric nanoparticles were purified and solidified, and then were evaluated of some properties and quality criteria.
Results: The formulation of andrographolide polymeric nanoparticles was choosen including dispersed-phase using Eudragid RL PO (eq. to ration of polymer/andrographolid was 4:1, w/w); the ratio of lecithin to andrographolid was 1:1; Tween 80 in water at concentration of 0.7% as a stabilizer; dispersed-phase volume was 150 mL. Finally, andrographolide polymeric nanoparticles were purified by centrifugal method and solidified to solid powder. After redispersion in water, the suspension sample containing andrographolid polymeric nanoparticle powder had a particle size of 203.2 ± 7.8 nm, a polydispersity index of 0.314 ± 0.007, and a Zeta potential of +53.2 ± 0.6 mV. TEM images showed that the particles were spherical in shape and in the nano range. The water solubility of andrographolide in polymeric nanoparticle was 4.51 times higher than that of the raw material. The encapsulation efficiency was 70.68%. The andrographolide content in the polymeric nanoparticle was 11.12%. In vitro release level showed that the polymeric nanoparticle improved the drug release level, prolong and control of the drug release process. FT-IR spectrum showed that there was no chemical interaction between andrographolide and the excipients during the preparation process. DSC spectrum showed that andrographolide existed in amorphous form in nanoparticles.
Conclusion: The andrographolide polymeric nanoparticle system were prepared and evaluated some properties and quality criteria.
Article Details
Keywords
andrographolide, polymeric nanoparticle, emulsification-evaporation technique
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