KẾT QUẢ LÂM SÀNG CHUYỂN ĐƠN PHÔI ĐÔNG LẠNH NGÀY 5 SỬ DỤNG MÔI TRƯỜNG GIÀU HYALURONAN TẠI BỆNH VIỆN ĐA KHOA PHƯƠNG ĐÔNG

Abstract

Objective: To evaluate the clinical outcomes of single day-5 frozen embryo transfer using a hyaluronan-enriched transfer medium. Methods: A retrospective descriptive study was conducted on 296 patients undergoing single day-5 blastocyst transfer, divided into two groups: 146 cases using conventional culture medium (CSC-C) and 150 cases using hyaluronan-enriched transfer medium (HETM). Results: There were no statistically significant differences in baseline characteristics between the two groups, including age, duration of infertility, BMI, antral follicle count (AFC) at the beginning of the cycle, AMH levels, history of miscarriage or stillbirth, and endometrial thickness on the day of progesterone initiation. Additionally, there was no significant difference in the quality of day-5 blastocysts between groups. Clinical outcomes, including rates of pregnancy, biochemical pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage, and live birth, were not significantly different between the groups (p > 0.05). Furthermore, no statistically significant improvement was observed in clinical outcomes with the use of HETM among patients with a history of recurrent miscarriage, stillbirth, or those receiving embryos of average quality (p > 0.05). Conclusion: The study indicates that the use of hyaluronan-enriched transfer medium in single day-5 blastocyst transfers does not improve clinical outcomes in in vitro fertilization.