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Date Published: 28/09/2025
Abstract Views: 11
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DOI: https://doi.org/10.56535/jmpm.v50i7.1386
Issue
Vol. 50 No. 7 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 7 - 2025
Section
Articles
How to Cite
Nguyễn , T. H. V., Nguyễn , T. H., Nguyễn, T. D., & Nguyễn, T. L. (2025). STUDY ON THE ACUTE AND SUB-CHRONIC TOXICITY OF BA GIANG HARD CAPSULES. Journal of Military Pharmaco-medicine, 50(7), 53-61. https://doi.org/10.56535/jmpm.v50i7.1386

STUDY ON THE ACUTE AND SUB-CHRONIC TOXICITY OF BA GIANG HARD CAPSULES

Thị Hồng Vinh Nguyễn 1, Thị Hà Nguyễn 2, Thái Dương Nguyễn3, Thị Liên Nguyễn1,
1 Viện Kiểm nghiệm Thuốc Trung ương
2 Nhà máy sản xuất thuốc YHCT Bà Giằng, Công ty cổ phần Dược phẩm Bagiaco - Chi nhánh Hà Nam
3 Công ty TNHH Novopharm

Main Article Content

Abstract

Objectives: To investigate the acute and subchronic toxicity of Ba Giang hard capsule. Methods: The acute toxicity of Ba Giang hard capsules were determined on Swiss mice. The subchronic toxicity of Ba Giang hard capsules were investigated on New Zealand White rabbits with the dose of 0.747 capsules/kg/day and 2.240 capsules/kg /day, the determination based on clinical, hematology test, biochemical and histopathology. Results: LD50 of Ba Giang hard capsules was more than the highest dose at which a sample can be administered 82.5 capsule/kg. Rabbits after treatment with dose 0.747 capsule/kg rabbit/day and 2.240 capsule/kg rabbit/day by oral for 28 days, rabbits are healthy, increase on weight. There is no significant difference between test groups and control group on the hematological and biochemical index. On histopathology of liver and kidney, there is no damage. Conclusion: Ba Giang hard capsules were not acute toxic and not subchronic toxic on animals.

Article Details

Keywords

Acute toxicity, Subchronic toxicity, Ba Giang hard capsules

References

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