ĐÁNH GIÁ ĐỘC TÍNH CẤP VÀ ẢNH HƯỞNG CỦA CHẾ PHẨM ĐỊNH TÂM NGỌC THÁI TỚI MỘT SỐ CHỈ SỐ HUYẾT HỌC TRÊN NGHIÊN CỨU THỰC NGHIỆM

Abstract

Objective

: To evaluate the acute toxicity in Swiss albino mice and the effects on hematological parameters in Wistar rats of the Dinh Tam Ngoc Thai preparation.

Methods

: Acute toxicity was assessed using the Litchfield–Wilcoxon method. The effects of the preparation on hematological parameters were evaluated according to WHO guidelines. Dosages were calculated in milliliters of the preparation.

Results

: Swiss albino mice were orally administered Dinh Tam Ngoc Thai at doses ranging from 25 ml/kg (equivalent to 186.90 g of medicinal herbs/kg body weight) to 150 ml/kg (equivalent to 101.40 g of medicinal herbs/kg body weight). After monitoring for 72 hours and up to 7 days post-administration, no mortality was observed. In Wistar rats that were given Dinh Tam Ngoc Thai for 28 consecutive days at doses of 7 ml/kg/day (equivalent to 4.732 g of medicinal herbs/kg/day) and 21 ml/kg/day (equivalent to 14.196 g of medicinal herbs/kg/day), no effects on hematological parameters were recorded.

Conclusion

: Dinh Tam Ngoc Thai is safe in acute toxicity evaluation in Swiss albino mice and does not affect hematological parameters when administered continuously for 28 days in Wistar rats