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NGHIÊN CỨU MỐI LIÊN QUAN CỦA NỒNG ĐỘ MMP-9 VÀ TIMP-1 HUYẾT TƯƠNG Ở THAI PHỤ TIỀN SẢN GIẬT
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Abstract
Objective: Determine the concentrations of MMP-9 and TIMP-1 in the plasma of normal pregnant women and pre-eclamptic pregnant women, and find out the relationship between MMP-9 and TIMP-1 concentrations in plasma with some symptoms of pre-eclampsia.
Subjects and methods: including two groups of pregnant women: normal pregnant women (control group n -120) and preeclamptic pregnant women (disease group n = 120). MMP-9 and TIMP-1 concentrations were determined by ELISA technique.Results: MMP-9 concentration in the plasma of preeclamptic pregnant women was 403.0 (207.6 – 794.1) ng/mL, lower than that of normal pregnant women, 608.6 (238.9 – 1212.0) ng/mL (p = 0.032). The concentration of TIMP-1 in the plasma of preeclamptic pregnant women is 196.8 (125.0 – 272.9) ng/mL and lower than in normal pregnant women is 225.8 (141.5 – 314.0) ng/mL (p = 0.14). The MMP-9/TIMP-1 ratio in preeclamptic 2.21 (1.39 – 3.20) was lower than normal pregnant women 2.83 (1.71 – 4.59), respectively, p = 0.008. There was a difference in plasma MMP-9 and TIMP-1 concentrations between the group of pregnant women with preeclampsia with grade 1 hypertension and pregnant women with grade 2 hypertension (p < 0.05). Conclusion: plasma MMP-9 concentration and MMP-9/TIMP-1 ratio in normal pregnant women are lower than in pre-eclamptic pregnant women. There is a relationship between plasma MMP-9 and TIMP-1 concentrations and the degree of hypertension in preeclamptic pregnant women.
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Keywords
Preeclampsia, MMP-9, TIMP-1, MMP-9/TIMP-1 ratio
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