CHẨN ĐOÁN GIẢI PHẪU BỆNH SINH THIẾT THẬN GHÉP THEO HỆ THỐNG PHÂN LOẠI BANFF NĂM 2022

Abstract

Objectives: The study aims to classify renal allograft pathology based on the updated 2022 Banff Classification. Methods: A cross-sectional descriptive study involving 195 patients who underwent renal allograft biopsy at Military Hospital 103 from January 2021 to December 2024. Results: Male patients accounted for 77.43%, with an average age of 38,94 ± 10,66 years. Living donors contributed to 98.98% of the cases. The most common cause of renal allograft dysfunction was rejection (49.23%), including antibody-mediated rejection (AMR) and T-cell-mediated rejection (TCMR). The earliest histological lesions were microvascular inflammation/injury (MVI) and acute AMR, occurring at an average of 0.13±0,07 and 0.58±1.19 months, respectively, while focal segmental glomerulosclerosis (FSGS) appeared the latest, at an average of 92±86.1 months. Patients of category 1 had mild increases in serum creatinine, while patients of category 6 had the highest creatinine levels.

Conclusions: The timing of the development of various etiologies and the use of prebiopsy serum creatinine levels can help in the prediction of etiology of renal dysfunction. However, due to the considerable diversity of allograft pathologies and ongoing updates in new classification, applying the 2022 Banff one is essential.