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Date Published: 28/06/2025
Abstract Views: 3
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DOI: https://doi.org/10.56535/jmpm.v50i5.1212
Issue
Vol. 50 No. 5 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 5 - 2025
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Articles
How to Cite
Dang, T. T., Đặng, T. C., & Trần, N. D. (2025). EVALUATION OF SOME PROGNOSTIC PATHOLOGICAL FEATURES IN TUMOR MICROENVIRONMENT IN COLORECTAL ADENOCARCINOMA. Journal of Military Pharmaco-medicine, 50(5), 114-122. https://doi.org/10.56535/jmpm.v50i5.1212

EVALUATION OF SOME PROGNOSTIC PATHOLOGICAL FEATURES IN TUMOR MICROENVIRONMENT IN COLORECTAL ADENOCARCINOMA

Thai Tra Dang1,2, , Thành Chung Đặng1, Ngọc Dũng Trần1
1 Bộ môn - Khoa Giải phẫu bệnh lý, Pháp y, Bệnh viện Quân y 103, Học viện Quân y
2 Bộ môn Sinh lý bệnh, Học viện Quân y

Main Article Content

Abstract

Objective: To evaluate the relationship between the tumor-infiltrating lymphocytes (TIL) and the tumor budding with prognostic pathological features in colorectal adenocarcinoma patients. Subjects and methods: A retrospective cross-sectional study of 176 colorectal adenocarcinoma patients at Military Hospital 103 from April 2021 to June 2024. TIL was evaluated according to ITWG 2014 and tumor budding according to ITBCC 2016 criteria. Results: The mean age was 66.03 ± 13.43; male/female ratio was 1.67/1. Low-grade TIL predominated (70.46%), while high-grade tumor budding accounted for 10.2%. Low-grade TIL was significantly associated with advanced tumor stage (p=0.015). High-grade tumor budding was correlated with poor differentiation (p=0.038), vascular (p<0.001) and perineural invasion (p=0.012). Conclusion: Tumor- infiltrating lymphocytes and tumor budding are closely associated with poor prognostic pathological features, confirming their roles as novel prognostic factors in colorectal adenocarcinoma.

Article Details

Keywords

Colorectal adenocarcinoma, Tumor- infiltrating lymphocytes, Tumor budding, Prognostic factors

References

1. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2024; 74(3):229-263.
2. Fuchs TL, Sioson L, Sheen A, et al. Assessment of Tumor-infiltrating Lymphocytes Using International TILs Working Group (ITWG) System is a strong predictor of overall survival in colorectal carcinoma: A study of 1034 Patients. Am J Surg Pathol. 2020; 44(4):536-544.
3. Lugli A, Kirsch R, Ajioka Y, et al. Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. Mod Pathol. 2017; 30(9):1299-1311.
4. Giraldo Nicolas A, Peske J David, Sautès-Fridman Catherine, et al. Integrating histopathology, immune biomarkers, and molecular subgroups in solid cancer: The next step in precision oncology. Virchows Archiv. 2019; 474(4):463-474.
5. Salgado R, Denkert C, Demaria S, et al. The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: Recommendations by an International TILs Working Group 2014. Ann Oncol. 2015; 26(2):259-271.
6. Nguyễn Thị Thanh Mai. Đặc điểm mô bệnh học và tình trạng mất ổn định vi vệ tinh của ung thư biểu mô tuyến đại trực tràng. Luận văn chuyên khoa cấp II, Trường Đại học Y Hà Nội. 2021.
7. Williams David S, Mouradov Dmitri, Newman Marsali R, et al. Tumour infiltrating lymphocyte status is superior to histological grade, DNA mismatch repair, and BRAF mutation for prognosis of colorectal adenocarcinomas with mucinous differentiation. Modern Pathology. 2020; 33(7):1420-1432.
8. van Wyk HC, Roseweir A, Alexander P, et al. The relationship between tumor budding, tumor microenvironment, and survival in patients with primary operable colorectal cancer. Ann Surg Oncol. 2019; 26(13):4397-4404.