ANTI – HLA ANTIBODIES BEFORE TRANSPLANTATION AND ASSOCIATION WITH SOME FACTORS IN PATIENT BEFORE KIDNEY TRANSPLANTATION

Abstract

Objectives: Survey of anti-HLA antibodies (PRA - Panel Reactive Antibodies) before transplanation and study of the relationship with some factors in patients before kidney transplant. Methods: Cross-sectional descriptive study in 152 patients receiving a kidney from a living donor, and post-transplant follow-up at Military Hospital 103, Vietnam Military Medical University (from April 2018 to April 2021). Results: The proportion of patients with positive anti-HLA antibodies before transplantation was 31.6%. Female patients had an average % of anti-HLA antibodies, and the rate of anti-HLA antibodies ≥ 10% was higher than male patients (p < 0.05). Blood transfusion and pregnancy are associated with developing anti-HLA antibodies. The risk of developing anti-HLA antibodies in the blood-transfusion group was higher than in the non-transfusion group (OR=2.793; p < 0.01). There was no correlation between pre-transplant HLA antibodies and age (p > 0.05). Conclusion: Pre-transplant PRA appears at a high rate (31.6%). Blood transfusion and pregnancy are risk factors for developing anti-HLA antibodies before kidney transplantation.