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Date Published: 28/06/2025
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DOI: https://doi.org/10.56535/jmpm.v50i5.1109
Issue
Vol. 50 No. 5 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 5 - 2025
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Articles
How to Cite
Nguyễn, T. H. V., Cao, V. Á., & Nguyễn, V. B. (2025). DEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR SIMULTANEOUS QUANTIFICATION OF PARACETAMOL AND METHOCARBAMOL IN TABLETS. Journal of Military Pharmaco-medicine, 50(5), 7-16. https://doi.org/10.56535/jmpm.v50i5.1109

DEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR SIMULTANEOUS QUANTIFICATION OF PARACETAMOL AND METHOCARBAMOL IN TABLETS

Thị Hồng Vân Nguyễn1, , Văn Ánh Cao1, Văn Bạch Nguyễn1
1 Học viện Quân y

Main Article Content

Abstract

Objective: To develop and validate a procedure for the simultaneous quantification of Paracetamol and Methocarbamol in tablets by high performance liquid chromatography (HPLC) in order to contribute to drug quality control. Subjects and methods: Quantitative Paracetamol and Methocarbamol by HPLC method with LunaR C18 (4 × 250 mm, 5µm), column temperature 26°C, flow rate 1.0 ml/min, detector UV at 274 nm, injection volume 10 µl, mobile phase consisting of acetonitril and 0.2 % formic acid in water with a gradient program. Results: The validation results for suitability, specificity, linearity, precision, and accuracy showed that this method was conformed to the ICH requirements. Conclusion: The quantitative method meets the requirements and can be used for the simultaneous quantification of Paracetamol and Methocarbamol in tablets.


* Keywords: Paracetamol, Methocarbamol, HPLC, tablets.

Article Details

Keywords

Paracetamol, Methocarbamol, HPLC, tablets

References

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