NGHIÊN CỨU SỰ THAY ĐỔI NỒNG ĐỘ PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE TRÊN BỆNH NHÂN XƠ GAN

Abstract

Objective: To investigate the relationship between plasma Proprotein convertase subtilisin/kexin type 9 (PCSK9) level and some paraclinical characteristics in patients with liver cirrhosis and to initially study the value of plasma PCSK9 level in liver cirrhosis. Methods: Prospective, cross-sectional description of 40 liver cirrhosis patients at the Gastroenterology Department - Military Hospital 103 and 40 control subjects. PCSK9 concentration in plasma was determined by Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: In patients with liver cirrhosis, PCSK9 level was moderately negative correlated with total Bilirubin (r = -0.314, p < 0.05) and moderately positive correlated with Prothrombin time ratio (r = 0.458, p < 0.01). The median plasma PCSK9 level in the cirrhotic group (100.0 ng/mL) was lower than that in the control group (144.8 ng/mL), p = 0.001. Plasma PCSK9 level had a moderate diagnostic value for liver cirrhosis (control group) with an AUC of 0.72 (0.61-0.83). At the cut-off point of 103.45 ng/mL, the sensitivity was 55.0%, the specificity was 85.0%, the positive predictive value was 78.6%, the negative predictive value was 65.4%, p = 0.001. Conclusion: Plasma PCSK9 level had the relationship with total bilirubin and prothrombin time ratio in liver cirrhosis patients. PCSK9 was considered useful for diagnosing of liver cirrhosis.