INVESTIGATION OF PLASMA GLUCAGON-LIKE PEPTIDE-1 LEVELS IN KIDNEY TRANSPLANT RECIPIENTS
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Abstract
Objectives: To investigate plasma glucagon-like peptide-1 (GLP-1) levels in kidney transplant recipients. Methods: A cross-sectional descriptive study was conducted on 81 kidney transplant recipients and 53 age- and sex-matched healthy controls at Military Hospital 103 from October 2021 to December 2023. Plasma GLP-1 concentrations were quantified in kidney transplant recipients and compared to the control group. Results: The median plasma GLP-1 concentration in kidney transplant recipients was 8.82 pmol/L, which was significantly lower than that of the control group (10.7 pmol/L, p < 0.001). A 8.6% reduction in GLP-1 levels was observed in the post-transplant group. In kidney transplant recipients, plasma GLP-1 levels demonstrated a negative correlation with age, the time after transplantations, insulin sensitivity (HOMA-S), and a positive correlation with insulin resistance (HOMA2-IR), p < 0.05. Insulin is an independent predictive factor for reducing plasma GLP-1, with OR = 0.578, p < 0.05. Conclusion: Plasma GLP-1 levels were decreased in kidney transplant recipients, with a reduction rate of 8,6%.
Keywords
Renal transplantation, Plasma glucagon-like peptide-1, HOMA
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References
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