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RISK CATEGORY IN PROGNOSIS OF INVASIVE BREAST CARCINOMA
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Abstract
Objective: determine the St Gallen risk categories rate of female breast cancer patients, and association with survival outcome.
Patients and method: Retrospective data from Bach Mai and Ha Noi cancer hospitals comprised 300 women who were diagnosed with breast cancer between January 1st, 2017, and June 31st, 2019, and were followed up to June 31st, 2024 (cut off point for follow-up). Patients were stratified according to the St Gallen risk categories. To evaluate survival, Kaplan-Meier and Cox-regression model was conducted.
Results: The risk groups rates were LR – 12.3%, IR1 – 60.3%, IR2 – 7%, HR1 – 9%, HR2 – 11.3% , respectively. The distribution of five year survival outcome by risk categories as follow: the overall survival (OS) rates were LR – 100%, IR – 93.6%, HR – 78.7%, respectively; the DFS rates were LR – 100%, 93.1%, HR – 88.5%, respectively. OS and DFS curves were significantly different between the three risk categories (p < 0.05). IR1 and IR2 had a distinctly different OS ( p = 0.009) but it was independent of DFS (p = 0.114). HR1 and HR2 hav no difference in OS and DFS (pOS = 0.078, pDFS = 0.246).
Conclusion: St Gallen risk category was useful in predicting the prognosis breast cancer patients.
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Keywords
Breast cancer, risk category, survival
References
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