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Date Published: 28/12/2024
Abstract Views: 7
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DOI: https://doi.org/10.56535/jmpm.v49i9.979
Issue
Vol. 49 No. 9 (2024): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 9 - 2024
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Articles
How to Cite
Ngô, T. H., Nguyễn, N. L., Nguyễn, H. A., & Trần, Đ. H. (2024). EVALUATION OF THE EFFECTIVENESS OF CONTINUOUS HEMOFILTRATION USING ADSORPTION MEMBRANES ON THE MANIFESTATION AND OUTCOMES OF TREATMENT OF SEPTIC SHOCK IN SEVERE BURN PATIENTS. Journal of Military Pharmaco-medicine, 49(9), 163-173. https://doi.org/10.56535/jmpm.v49i9.979

EVALUATION OF THE EFFECTIVENESS OF CONTINUOUS HEMOFILTRATION USING ADSORPTION MEMBRANES ON THE MANIFESTATION AND OUTCOMES OF TREATMENT OF SEPTIC SHOCK IN SEVERE BURN PATIENTS

Tuấn Hưng Ngô1,2, , Như Lâm Nguyễn1,2, Hải An Nguyễn1,2, Đình Hùng Trần1,2
1 Bộ môn Bỏng và Y học Thảm họa, Học viện Quân y
2 Bệnh viện Bỏng Quốc gia Lê Hữu Trác

Main Article Content

Abstract

Objectives: Evaluation of the effectiveness of continuous hemofiltration using adsorption membranes (HFA) on the manifestation and outcomes of treatment of septic shock in severe burn patients. Subjects and methods: Prospective, interventional study of 55 episodes of septic shock in 38 severely burned patients (16-60 years old) receiving continuous hemofiltration with oXiris membranes, treated at the Department of Emergency Resuscitation, Le Huu Trac National Burn Hospital from January 2023 to June 2024. Study time points: at diagnosis of septic shock (T1), time of HFA (T2), after 6 hours of HFA (T3), 12 hours of HFA (T4), 24 hours of HFA (T5) and 48 hours of HFA (T6). Results: The mortality rate was 60.53. In 55 episodes of septic shock, there were 36 shock episodes escapes (65.45%). During HFA, there was a significant reduction in SOFA score (T2: 8 (7 – 9), T4: 7 (6 – 8), T5: 6 (5 – 8), T6: 5 (2 – 8), p < 0.001), Vasoactive -Inotropic Score (T2: 30 (20 – 50), T3: 20 (15 – 40), T4: 15 (10 – 30), T5: 5 (3 – 30), T6: 0 (0 – 20), p < 0.001) and arterial blood lactate concentration (T1: 2.6 (2.3 – 3.4) mmol/L, T3: 1.9 (1.3 – 2.6) mmol/L, T4: 1.9 (1.2 – 2.4) mmol/L, T5: 1 .8 (1.3 – 2.5) mmol/L, T6: 1.8 (1.3 – 2.5) mmol/L, p < 0.001). Conclusion: Continuous hemofiltration with adsorption membrane significantly reduced SOFA, Vasoactive -Inotropic Score and arterial blood lactate concentration.

Article Details

Keywords

Septic shock, severe burns, continuous hemofiltration

References

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