NGHIÊN CỨU MỘT SỐ ĐẶC ĐIỂM NHIỄM BK VIRUS Ở BỆNH NHÂN SAU GHÉP THẬN

Abstract

Objectives: To investigate some characteristics of BKV infection and analyze relations between infection with some clinical and subclinical features in patients after kidney transplant. Subjects and methods: 360 post-kidney transplant patients were treated and monitored at Military Hospital 103 and 108 Military Central Hospital, from October 2020 to June 2024. Patients had pre-transplant data collected, had clinical examinations, performed routine tests, measured BK virus load in blood and urine at the time of the study, and performed kidney allograft biopsies as indicated. Results: The proportion of patients with BKV infection positive was 56.7%. The rate of BKV infection was significantly positive at 41.3%. BKVN rate is 3.1%. BKV load in blood had a moderate positive correlation with BKV load in urine, r = 0.524, p < 0.001. BKV-infected group had lower mean GFR and hemoglobin than BKV-uninfected group, p < 0.05. The BKVN group had statistically significantly lower mean GFR and hemoglobin, longer post-transplant time, higher rate of positive proteinuria, and higher rate of patients receiving Tac than the BKV-positive group without BKVN. There was a negative correlation between BKV load in blood and urine with GFR, r = -0.263 and r = -0.147, respectively, p < 0.05. Conclusions: The rate of BKV infection in patients after kidney transplant is relatively high. BKV infection causes reduced kidney graft function. Long-time post-transplant and use of Tacrolimus increase the rate of BKVN.