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MEASURING SERUM PROGESTERONE CONCENTRATION ONE DAY PRIOR TO FROZEN EMBRYO TRANSFER IMPROVES PREGNANCY OUTCOME
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Abstract
Objective: To evaluate the relationship between serum progesterone concentration one day prior to frozen embryo transfer and the 12-week ongoing pregnancy rate. Subjects and methods: A descriptive, prospective study of 120 cycles of frozen blastocyst transfer at the Military Institute of clinical Embryology and Histology, using hormone replacement therapy for endometrial preparation and 800mg vaginal micronized progesterone plus 20mg oral dydrogesterone for luteal phase support. Serum progesterone was measured one day before embryo transfer. Results: Multivariate logistic regression analysis for factors predicting the ongoing pregnancy rate, P4 concentration before embryo transfer was the only factor had a statistically significant difference (p = 0.026, OR: 0.93, 95%CI: 0.87-0.99). The ROC curve predicting the outcome of onggoing pregnancy using serum P4 concentration had an AUC of 0.616. The cut-off value of P4 predicting the outcome of onggoing pregnancy was 14.715 ng/mL, sensitivity 55.7%, specificity 72.9%. Conclusion: Serum progesterone concentration one day before frozen blastocyst transfer > 14.715 ng/mL is associated with a lower ongoing pregnancy rate.
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Keywords
progesterone, frozen embryo transfer, ongoing pregnancy
References
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