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CHANGES IN GLOMERULAR FILTRATION RATE ONE YEAR AFTER KIDNEY DONATION
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Abstract
Background: Living kidney donors (LKD) typically do not receive any benefit from their donation, nor do they anticipate any. Therefore, in addition to careful assessment and selection before kidney donation, kidney donors deserve monitoring and support to ensure optimal long-term health. This helps to maintain trust in the process of kidney donation and transplantation.
Objectives: To investigate the impact of kidney donation on glomerular filtration rate in the first year of live kidney donation and some factors associated with early changes in glomerular filtration rate.
Subjects and methods: The retrospective study was conducted on 189 living kidney donors in the Cho Ray Hospital’s outpatient department from January 2014 to December 2020.
Results: A total of 189 LKD were analysed. There were 106 females (56.1%) and 83 males (43.9%), the mean age was 49.68±9.00 years, and the baseline (pre-donation) eGFR was 88.74 ± 13.27 mL/min/1.73m2. One month after donation, the mean eGFR was 65.19 ± 10.56 mL/phút/1,73m2, decreased by 26.5% (p<0.001). The change in eGFR between one month to one year was 5.49±9.85 mL/min/1.73m2 (p<0.001). There was a slightly negative correlation between pre-donation serum cystatin C (-0.17), mGFR (-0.16), and change in eGFR after one year of donation (p<0,05).
Conclusions: Kidney donation is safe, and GFR gradually improves after donation due to compensatory adaptations. Cystatin C level and mGFR before donation correlate with a more significant reduction in eGFR one year after kidney donation. Regular monitoring and prompt management of potential issues post-kidney donation are essential for ensuring long-term health and well-being.
Article Details
Keywords
estimated glomerular filtration rate, living kidney donors, risk factors
References
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