Article Sidebar

PDF
Date Published: 06/10/2024
Abstract Views: 2
Views PDF: 0
DOI: https://doi.org/10.56535/jmpm.v49si1.939
Issue
Vol. 49 No. si1 (2024): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ - SỐ ĐẶC BIỆT 10/2024
Section
Hội nghị Khoa học Ghép tạng toàn quốc lần thứ IX
How to Cite
Đinh, T. H., Phan, B. N., & Lê, V. T. (2024). SERUM TESTOSTERONE CONCENTRATION CHANGES IN MEN KIDNEY TRANSPLANT RECIPIENTS AT MILITARY HOSPITAL 103. Journal of Military Pharmaco-medicine, 49(si1), 113-122. https://doi.org/10.56535/jmpm.v49si1.939

SERUM TESTOSTERONE CONCENTRATION CHANGES IN MEN KIDNEY TRANSPLANT RECIPIENTS AT MILITARY HOSPITAL 103

Trọng Hà Đinh1, Bá Nghĩa Phan2, , Việt Thắng Lê2
1 Bộ môn Sinh lý học, Học viện Quân y
2 Bệnh viện Quân y 103, Học viện Quân y

Main Article Content

Abstract

Objectives: To assess changes in serum testosterone concentration in men kidney transplant recipients from living donors at Military Hospital 103. Methods: This was a prospective, longitudinal, descriptive study with analysis conducted on 45 men patients who successfully underwent kidney transplantation from March 2023 to May 2024. Results: The mean serum testosterone concentration in men kidney transplant recipients was 13.64 (11.4–15.99) nmol/L, a statistically significant improvement compared to pre-transplant (12.09 (10.09–15.0) nmol/L), p=0.04; 13.33% (6/45 patients) had reduced serum testosterone concentration, with 8.89% of new cases occurring post-transplant. The serum testosterone concentration had a significant positive correlation with IIEF-5 score (erectile function assessment), r=0.32, p=0.031. Logistic regression analysis indicated that the trough concentration C0 of Tacrolimus was an independent factor associated with the occurrence of reduced serum testosterone level in men kidney transplant recipients, OR=1.933 (CI95% 1.008 – 3.707). Conclusion: Serum testosterone concentration in men patients 6 months after kidney transplantation improved compared to pre-transplant but remained low, associated with erectile dysfunction and tacrolimus trough concentrations.

Article Details

Keywords

Kidney transplant, Testosterone, IIEF-5 score

References

1. Suzuki E. Chronic kidney disease and erectile dysfunction. WJN. 2014; 3(4):220.
2. Livingston M, Kalansooriya A, Hartland AJ, et al. Serum testosterone levels in male hypogonadism: Why and when to check-A review. Int J Clin Pract. 2017; 71(11):e12995.
3. Lofaro D, Perri A, Aversa A, et al. Testosterone in renal transplant patients: Effect on body composition and clinical parameters. J Nephrol. 2018; 31(5):775-783.
4. Gungor O, Kircelli F, Carrero JJ, et al. Endogenous testosterone and mortality in male hemodialysis patients: Is it the result of aging? Clin J Am Soc Nephrol. 2010; 5(11):2018-2023.
5. Mai Thế Trạch. Hằng số sinh lý về nội tiết. Nội tiết học đại cương. Nhà xuất bản Y học, Hà Nội. 1999:596-597.
6. Jabali SS, Saleem ZSM, Mohammed AA, et al. Erectile dysfunction pre and post kidney transplant recipients in Duhok city; cross-sectional study. Annals of Medicine and Surgery. 2020; 55:107-110.
7. El-Bahnasawy MS, El-Assmy A, El-Sawy E, et al. Critical evaluation of the factors influencing erectile function after renal transplantation. Int J Impot Res. 2004; 16(6):521-526.
8. Perri A, Izzo G, Lofaro D, et al. Erectile dysfunction after kidney transplantation. JCM. 2020; 9(6):1991.
9. Albaaj F, Sivalingham M, Haynes P, et al. Prevalence of hypogonadism in male patients with renal failure. Postgraduate Medical Journal. 2006; 82(972):693-696.
10. Rahman IA, Rasyid N, Birowo P, et al. Effects of renal transplantation on erectile dysfunction: A systematic review and meta-analysis. Int J Impot Res. 2022; 34(5):456-466.