ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ KHÁNG THUỐC Ở BỆNH NHÂN LAO PHỔI KHÁNG THUỐC LAO HÀNG THỨ NHẤT

Abstract

Objective: To describe the clinical, paraclinical characteristics and anti-tuberculosis drug resistance in patients with pulmonary tuberculosis resistant to first-line anti-tuberculosis drugs. Subjects and methods: A cross-sectional prospective study carried on 64 pulmonary tuberculosis patients with first-line drug-resistance treated at the Central Lung Hospital from January 2023 to June 2024. Results: The proportion of men is 59.43%, the average age is 46.78 ± 16.89 years old, and new tuberculosis accounts for 70.31%. Common symptoms are prolonged cough and sputum (93.75%), and rales in the lungs (85.94%). The rate of X-ray images with both 2 lung lesions is 53.12%, with cavernous lesions of 39.06%. The rate of combined resistance to many different drugs is higher than single-drug resistance (60.94% compared to 39.06%). The rate of drug resistance in the treated TB group was higher than that in the new TB group for R, E, PZA and S. The proportions of resistance to R, INH, PZA, E and S follow by 42.19%; 87.5%; 29.69%; 18.75% and 64.06. The rates of resistance to 3 drugs, 4 drugs and 5 drugs are 18.75%; 15.62% and 12.5%, and higher in pulmonary tuberculosis group with a history of tuberculosis treatment. Conclusions: Patients with pulmonary tuberculosis resistant to first-line tuberculosis drugs are common in middle-aged men, the majority of new tuberculosis patients (70.31%), with many clinical symptoms, extensive lung lesions and cavities on Chest X-ray images, combined resistance to many different drugs and high rate of drug- resistance in groups with previous treatment history.