ĐÁNH GIÁ TÁC DỤNG PHỤ CỦA DUNG DỊCH NHỎ MẮT ATROPINE 0,05% TRONG KIỂM SOÁT TIẾN TRIỂN CẬN THỊ

Abstract

Backgroud: The current review found Atropine eye drops were the most efficacious intervention in myopia progression control. Although high-dose atropine (≥ 0.5%) has been slowing down myopia > 90%  in progression of myopia, but  higher concentration are more likely to cause adverse events and may increase the risk of rebound following cesation of treatment. The optimal atropine concentration should be the one with the best balance between efficacy and safety. 0.05% Atropine was assessed the most beneficial concentration for controlling myopia progression.

Purpose: To evaluate change in visual acuity, pupil size, accommodation amplitude, corneal curvature, intraocular pressure, side effects in the 0.05% atropine eye drops compared to those using 0.9% Sodium Chloride eye drops.

Participants and Methods: Single - blinded, randomized, placebo-controlled trial involving 106 eyes (53 children) aged 7 to 12 years who were diagnosed myopia at Can Tho Eye – Odontology Hospital in 01/2023 – 10/2023.

Results: The mean change in  accommodation amplitude -3,3 ± 3,4D and photopic pupil size 0,6 ± 0,9mm in the Atropine group compared to 0,6 ± 3,8D (p<0.001) and  - 0,01 ± 0,7 (p<0.01) in the placebo group, respectively; BCVA, near visual acuity, corneal curvature, intraocular pressure were not significant between 2 groups. Except for photophobia, side effects were similar across all groups.

Conclusions: Side effects of 0.05% Atropine eye drops changed accommodation amplitude, increased photopic pupil size that caused photophobia at the 2-week visit and reduced over time 6 months. Visual acuity, corneal curvature, intraocular pressure did not change significantly from baseline and between 2 groups.