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MACULAR VASCULAR FLOW DENSITY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN HIGH MYOPIA
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Abstract
MACULAR VASCULAR FLOW DENSITY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN HIGH MYOPIA
ABSTRACT
Purpose: to describe changes in retinal capillaries in the superficial and deep layers, choriocapillaris layer in the macular area in the high myopes using OCT-A.
Methods: cross-sectional study; a total of 30 eyes (17 patients) from 18 to 45-years-old high myopes with axial length (AL) ≥ 26.0 mm and spherical equivalent at -6.0 diopters (D) or worse were recruited and divided into 2 groups: high myopia (21 eyes) and pathologic myopia (9 eyes) according to the clinical grading of myopic maculopathy. Macular angiography was recorded by using the OCT-A Carl Zeiss Cirrus 5000.
Results: The spherical degree of the pathologic myopia group is -11.11 ± 3.68 D, with a significant difference compared to the high myopia group of -8.02 ± 1.38 (p=0.037); The BCVA (best corrected visual acuity) of the pathologic myopia group (0.34 ± 0.36) was different from the high myopia group (0.05 ± 0.05) with p = 0.041; The axial length of the pathologic myopia group (29.74 ± 2.39 mm) was significantly longer than the high myopia group (27.25 ± 1.29 mm); The vascular flow density of the pathologic myopia group in the superficial and deep retinal layers decreased significantly in all regions, except the central location in the deep layer with p = 0.050; At the choriocapillaris layer, a statistically significant difference was only noted at the central location (p=0.007).
Conclusions: The elongation of the axial length and the progression of spherical equivalent refraction in the pathologic myopia group resulted in the reduction of the density of retinal and choroidal capillaries in the macular area, compared to the high myopia group.
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Keywords
high myopia, pathologic myopia, OCT-A.
References
2. WHO. The impact of myopia and high myopia: Report of the joint world health organization - brien holden vision institute global scientific meeting on Myopia, University of New South Wales, Sydney, Australia. 16-18 March 2015. 2017;
3. Williams K, Hammond C. High myopia and its risks. Community Eye Health. 2019; 32(105):5-6.
4. Min CH, Al-Qattan HM, Lee JY, Kim JG, Yoon YH, Kim YJ. Macular microvasculature in high myopia without pathologic changes: An optical coherence tomography angiography study. Korean J Ophthalmol. Apr 2020; 34(2):106-112. DOI: 10.3341/kjo.2019. 0113.
5. Ohno-Matsui K, Wu PC, Yamashiro K, et al. IMI Pathologic Myopia. Invest Ophthalmol Vis Sci. Apr 28 2021; 62(5):5. DOI: 10.1167/iovs.62.5.5.
6. Malamos P, Tsolkas G, Kanakis M, et al. OCT-Angiography for monitoring and managing neovascular age-related macular degeneration. Curr Eye Res. Dec 2017; 42(12):1689-1697. DOI: 10.1080/02713683.2017.1356336.
7. Al-Sheikh M, Akil H, Pfau M, Sadda SR. Swept-Source OCT angiography imaging of the foveal avascular zone and macular capillary network density in diabetic retinopathy. Invest Ophthalmol Vis Sci. Jul 1 2016; 57(8):3907-3913. DOI: 10.1167/iovs. 16-19570.
8. Mo J, Duan A, Chan S, Wang X, Wei W. Vascular flow density in pathological myopia: An optical coherence tomography angiography study. BMJ Open. Feb 3 2017; 7(2):e013571. DOI: 10.1136/bmjopen-2016-013571.
9. Walaa ME, Tarek AM, Heba RA, Rabei MH. Macular microvasculature evaluation using optical coherence tomography angiography in patients with high myopia. 2019; 6(2):43-51. DOI: 10.4103/erj.erj_12_19.
10. Ucak T, Icel E, Yilmaz H, et al. Alterations in optical coherence tomography angiography findings in patients with high myopia. Eye (Lond). Jun 2020; 34(6):1129-1135. DOI: 10.1038/s41433-020-0824-1.