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Date Published: 28/09/2024
Abstract Views: 10
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DOI: https://doi.org/10.56535/jmpm.v49i7.830
Issue
Vol. 49 No. 7 (2024): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 7 - 2024
Section
Articles
How to Cite
Dương, T. H. Á., & Tôn, T. T. (2024). PREPARATION OF BERBERIN CHLORIDE FLOATING MICROSPHERES. Journal of Military Pharmaco-medicine, 49(7), 7-17. https://doi.org/10.56535/jmpm.v49i7.830

PREPARATION OF BERBERIN CHLORIDE FLOATING MICROSPHERES

Thị Hồng Ánh Dương1, , Thị Thúy Tôn2
1 Trường Đại học Dược Hà Nội
2 Công ty Cổ phần Dược phẩm Trung ương I-Pharbaco

Main Article Content

Abstract

Objectives: To develop floating microspheres of berberin chloride. Methods: The floating microspheres were prepared by ionotropic gelation using different concentrations of sodium alginate, hydroxypropyl methyl cellulose K100LV, sodium bicarbonate, calcium chloride and the drug. The floading microspheres were characterized for particle size, tapped density, floating lag time and floating time, drug loading amount, percentage yield and in vitro drug release. Results: The final BBR microspheres contained BBR 100.00 mg, sodium alginate 200.00 mg, hydroxypropyl methylcellulose K100LV 10.00 mg, calcium carbonate 250.00 mg, sodium bicarbonate 250.00 mg and calcium chloride dihydrate 400.00 mg. The suitable formulation had a particle size of 0,94 ± 0,04 (mm), floating time 8 hours in hydrochloric acid pH 1.2 containing 0.2% Tween 80 and showed 90.70% drug release in 24 hours. Conclusion: The study has prepared berberin chloride floating microspheres.

Article Details

Keywords

Berberin chloride, floating microspheres, ionotropic gelation

References

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