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Date Published: 28/08/2024
Abstract Views: 13
Views PDF: 5
DOI: https://doi.org/10.56535/jmpm.v49i6.814
Issue
Vol. 49 No. 6 (2024): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 6 - 2024
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Articles
How to Cite
Bùi, K. C. (2024). PROTEIN KINASE INHIBITOR TAK-901 ACTIVATES APOPTOSIS ON COLONRECTAL CANCER CELLS. Journal of Military Pharmaco-medicine, 49(6), 28-35. https://doi.org/10.56535/jmpm.v49i6.814

PROTEIN KINASE INHIBITOR TAK-901 ACTIVATES APOPTOSIS ON COLONRECTAL CANCER CELLS

Khắc Cường Bùi1,
1 Trung tâm nghiên cứu động vật thực nghiệm, Học viện quân y

Main Article Content

Abstract

Objectives: TAK-901 is a substance that inhibits many protein kinases, including Aurora A/B, JAK3... important proteins that affect the survival of cancer cells. This study was conducted to evaluate the impact of TAK-901 on proliferation and apoptosis of colorectal cancer cells. Methods: Research using protein kinase inhibitor TAK-901 and colon cancer cell line HCT116. Exprimental assays were applied including the crystal violet assay and the apoptosis assay using flow cytometry system. Results: Protein kinase inhibitor TAK-901 inhibited cell proliferation in the crystal violet assay and activated programmed cell death in the apoptosis assay on colorectal cancer cell lines HCT-116. Conclusion: Protein kinase inhibitor TAK-901 inhibited proliferation and activated programmed cell death on colorectal cancer cell line HCT-116.

Article Details

Keywords

Protein kinase, TAK-901, colonrectal cancer

References

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