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The value of ultrasound for liver fat quantification by using LFQ technique to evaluate hepatic steatosis referenced with MRI-PDFF
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Abstract
Objective: The goals of this study were to determine the value of ultrasound for liver fat quantification by using LFQ to evaluate hepatic steatosis.
Methods: A prospective cross-sectional descriptive study was performed on 38 patients, who voluntarity underwent liver ultrasound with B mode for qualitative assessment of fatty liver, measurment of attenuation coefficient (AC) by using LFQ technique and MRI-PDFF at 360 Le Hoan general clinic from september to december 2023. Grading hepatic steatosis on MRI-PDFF based on previous study for reference with fat fraction (FF) < 5,2% (S0: Not fatty liver), FF ³ 5,2% (S1: Grade 1 fatty liver), FF ³ 11,3% (S2: Grade 2 fatty liver) and FF ³ 17,1% (S3: Grade 3 fatty liver). The sensitivity (Se), specificity (Sp) and AUC of ultrasound for liver fat quantification were calculated by ROC analysis and the cut-off value of attenuation coefficient were also defined.
Results: There were 38 patients with 22 males (57,9%) and 16 females (42,1%), average age 50,6. There were 13 patients without fatty liver (34,2%) and 25 patients with fatty liver (65,8%), who were determined on MRI-PDFF with FF < 5,2% and ³ 5,2% respectively. Out of 25 patients with fatty liver on MRI-PDFF, there were 8 (32,0%) patients without overweight or obese (BMI < 23). Ultrasound B mode confirmed only 16/25 patients (64,0%) of those with fatty liver on MRI-PDFF. The cut-off value of AC by LFQ technique were 0,62; 0,66 and 0,66 dB/cm/MHz corresponding to ³ S1 (FF ³ 5,2%), ³ S2 (FF ³ 11,3%) and ³ S3 (FF ³ 17,1%) on MRI-PDFF respectively. ROC curve analysis showed the sensitivity (Se), specificity (Sp), cut-off of AC as also AUCs that were 76,6%, 45,2%, 0,62, 76,6% respectively coressponding to ³ S1 and 80,0%, 65,7%, 0,66, 90,9% to ³ S2 respectively.
Conclusion: Ultrasound for liver fat quantification with LFQ technique by measurment of attenuation coefficient (AC) was valuable in evaluating hepatic steatosis. This technique was a simple, easy to do on the available ultrasound systems, low-cost technique that could be widely applied.
Article Details
Keywords
Liver fat quantification, MRI-PDFF, Ultrasound quantification of the hepatic steatosis
References
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