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Date Published: 03/05/2024
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DOI: https://doi.org/10.56535/jmpm.v49.799
Issue
Vol. 49 (2024): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ - SỐ ĐẶC BIỆT 5/2024
Section
CDHA
How to Cite
Mai, H. T., Mai, H. S., Bùi, Q. B., Vũ, T. L., Nguyễn, M. T., & Le, N. H. (2024). THE ROLE OF 18F-FDG PET/CT METABOLISM PARAMETERS IN PREDICTING TREATMENT RESPONSE AFTER NEOADJUNCTIVE CHEMOTHERAPY WITH GP REGIMEN IN PATIENTS NASOPHARYNGEAL CANCER STAGES III, IVA. Journal of Military Pharmaco-medicine, 49, 91-102. https://doi.org/10.56535/jmpm.v49.799

THE ROLE OF 18F-FDG PET/CT METABOLISM PARAMETERS IN PREDICTING TREATMENT RESPONSE AFTER NEOADJUNCTIVE CHEMOTHERAPY WITH GP REGIMEN IN PATIENTS NASOPHARYNGEAL CANCER STAGES III, IVA

Huy Thông Mai, Hồng Sơn Mai, Quang Biểu Bùi, Thị Ly Vũ, Minh Tuấn Nguyễn, Le Ngoc Ha

Main Article Content

Abstract

Objective: Studying the role of 18F-FDG PET/CT metabolic parameters in predicting response after neoadjuvant chemotherapy with GP regimen in patients with stage III, IVA nasopharyngeal cancer. Subjects and Methods: Retrospective combined prospective study on 43 patients with stage III and IVA nasopharyngeal cancer who had PET/CT scans before treatment and were treated with neoadjuvant chemotherapy using the GP regimen. Measurement of metabolic parameters on 18F-FDG PET/CT images. Enter and process data on SPSS 20.0 and Medcalc 20 software. Results: The optimal threshold values of MTV, SUVmax, SUVmean, SUVpeak, TLG to predict complete treatment response are 15,97; 13,29; 7,71; 10,24 and 118,07, respectively. Univariate analysis showed that SUVmax, SUVmean, SUVpeak, TLG were significantly associated with the prognosis of complete response after NAC treatment using the GP regimen with the given threshold values. In multivariate analysis, complete non-responders were significantly associated with TLG ≥ 118,07 (OR,15,5; 95% CI, 1,17 – 206,11; p< 0.05) with sensitivity, specificity and accuracy were 91,3%; 60%; 72,1%. Conclusion: TLG with the optimal threshold value of 118.07 has independent prognostic value for complete response after NAC treatment with GP regimen in patients with stage III and IVA nasopharyngeal cancer with sensitivity, specificity and accuracy of 91,3%; 60%, 72,1%.

Article Details

Keywords

nasopharyngeal cancer, 18F-FDG PET/CT metabolic parameters, response treatment

References

1. Pan JJ, Ng WT, Zong JF, et al. Proposal for the 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy. Cancer. 2016; 122:546-558.
2. Sun Y, Li WF, Chen Ny, et al. Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: A phase 3, multicentre, randomised controlled trial. Lancet Oncol. 2016; 17:1509-1520.
3. Boellaard R, Delgado-Bolton R, Oyen WJ, Giammarile F, Tatsch K, Eschner W, et al. FDG PET/CT: EANM procedure guidelines for tumour imaging: Version 2.0. Eur J Nucl Med Mol Imaging. 2015; 42(2):328-354.
4. Jinbing Zhu 1, Baofeng Duan et al. Comparison of GP and TPF induction chemotherapy for locally advanced nasopharyngeal carcinoma. Oral Oncol. 2019 Oct; 97:37-43. DOI: 10.1016/j.oraloncology.2019.08.001.
5. Dagogo-Jack I, Shaw AT. Tumour heterogeneity and resistance to cancer therapies. Nat Rev Clin Oncol. 2018; 15(2):81-94.
6. Lee JW, Park JY, Lee HJ, et al. Preoperative 18F-FDG PET/CT tumour heterogeneity index in patients with uterine leiomyosarcoma: A multicentre retrospective study. Eur J Nucl Med Mol Imaging. 2018; 45(8):1309-1316.
7. Jijin Yao, Ying Wang, et al. The role of pretreatment 18F-FDG PET/CT for early prediction of neoadjuvant chemotherapy response in patients with locoregionally advanced nasopharyngeal carcinoma. Drug Des Devel Ther. 2021; 15:4157-4166.