BRAINSTEM GLIOMA: PREDICTION OF HISTOPATHOLOGIC GRADE BASED ON CONVENTIONAL MR IMAGING

Văn Lâm Tạ, Thanh Dũng Lê, Nguyen Duy Hung

Main Article Content

Abstract

Objectives: A retrospective study was designed to investigate the value features on MR imaging in differentiating low-grade and high-grade brainstem gliomas. Methods: Retrospective study was performed in 36 patients including 20 children and 16 adults, with pathological results of brainstem glioma. Analysis features of brainstem glioma on conventional MRI to determine the sensitivity, specificity of signs to help distinguish low-grade and high-grade. Results: In children, tumors located in the midbrain, in the tectorial membrane, invading the fourth ventricle, localized, and having cystic components have the value of suggesting low-grade brainstem glioma with sensitivity and specificity of each sign are 83.3% and 71.4%, 50% and 100%, 50% and 92.9%, 33.3% and 100%, 50% and 92.9%, respectively. Tumors have diffusetively and hemorrage components suggest high-grade brainstem glioma with sensitivity and specificity of each sign being 100% and 33.3%, 64.3% and 100%, respectively. In adults, hemorrage components have a suggestive value of high-grade brainstem glioma with sensitivity and specificity of 50% and 100%. Conclusion: In children, location in the midbrain/tectum, focal lesions, invasion of the fourth ventricle, cystic component suggest low-grade brainstem glioma, diffuse and hemorrage suggest high-grade brainstem glioma. In adults, hemorrage characteristics suggest high-grade brainstem glioma.

Article Details

References

1. Purohit B, Kamli AA, Kollias SS. Imaging of adult brainstem gliomas. European Journal of Radiology. 2015; 84(4):709-720. DOI: 10.1016/j.ejrad. 2014.12.025.
2. Louis DN, Perry A, Wesseling P, et al. The 2021 WHO classification of tumors of the central nervous system: A summary. Neuro-Oncology. 2021; 23(8):1231-1251. DOI: 10.1093/neuonc/ noab106.
3. Lam S, Lin Y, Auffinger B, Melkonian S. Analysis of survival in pediatric high-grade brainstem gliomas: A population-based study. Journal of Pediatric Neurosciences. Jul-Sep 2015; 10(3):199-206. DOI: 10.4103/1817-1745.165656.
4. Reithmeier T, Kuzeawu A, Hentschel B, Loeffler M, Trippel M, Nikkhah G. Retrospective analysis of 104 histologically proven adult brainstem gliomas: Clinical symptoms, therapeutic approaches and prognostic factors. BMC Cancer. 2014/02/21 2014; 14(1):115. DOI: 10.1186/1471-2407-14-115.
5. Samadani U, Judy KD. Stereotactic brainstem biopsy is indicated for the diagnosis of a vast array of brainstem pathology. Stereotactic and Functional Neurosurgery. 2003; 81(1-4):5-9. DOI: 10.1159/000075097.
6. Rachinger W, Grau S, Holtmannspötter M, Herms J, Tonn J-C, Kreth FW. Serial stereotactic biopsy of brainstem lesions in adults improves diagnostic accuracy compared with MRI only. Journal of Neurology, Neurosurgery & Psychiatry. 2009; 80(10):1134-1139. DOI: 10.1136/jnnp. 2009.174250.
7. Li X, Morgan PS, Ashburner J, Smith J, Rorden C. The first step for neuroimaging data analysis: DICOM to NIfTI conversion. Journal of Neuroscience Methods. 2016/05/01/ 2016; 264:47-56. DOI: 10.1016/j.jneumeth. 2016.03.001.
8. Sarma A, Heck JM, Ndolo J, Newton A, Pruthi S. Magnetic resonance imaging of the brainstem in children, part 1: Imaging techniques, embryology, anatomy and review of congenital conditions. Pediatric Radiology. 2021/02/01 2021; 51(2):172-188. DOI: 10.1007/s00247-020-04953-1.
9. Moharamzad Y, Sanei Taheri M, Niaghi F, Shobeiri E. Brainstem glioma: Prediction of histopathologic grade based on conventional MR imaging. The Neuroradiology Journal. 2018; 31(1):10-17. DOI: 10.1177/ 1971400917743099.
10. Epstein FJ, Farmer JP. Brain-stem glioma growth patterns. Journal of Neurosurgery. Mar 1993; 78(3):408-12. DOI: 10.3171/jns.1993.78.3.0408.