ĐỘC TÍNH ĐƠN LIỀU VÀ ĐẶC ĐIỂM HÌNH ẢNH PET/CT CỦA DƯỢC CHẤT PHÓNG XẠ GALLIUM-68 PSMA I&T TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Objective: To evaluate single dose toxicity of radiopharmaceutical ⁶⁸Ga-PSMA I&T prepared on an automatic synthesis module iQS-TS (ITM, Germany) installed at the Nuclear Medicine Department, 108 Military Central Hospital, and imaging distribution of the radiopharmaceutical in animal with positron emission tomography (PET/CT) scanner. Materials and methods: ⁶⁸Ga-PSMA I&T was produced at the Nuclear Medicine Department by an automatic synthesis module iQS-TS. The animals Swiss mice were then injected doses approximately 10 mCi/kg of weight, as 100 times higher as than the equivalent human dose. The NewZealand rabbits were injected with a dose for PET/CT imaging. Result: After 14 days and 24 hours of radiopharmaceutical injection with the dose of 10 mCi per kilogram of weight. The results of hematology and biochemistry tests, weight and relative organ weight measuring of the testing groups are not statistically significant when compared to the control groups injected with saline 0,9%. In addition, the results of histology and pathology of kidneys and livers from the two mice groups show no abnormality. The PET/CT images show a high uptake in kidneys, bladder, liver, spleen and salivary glands with the standardized uptake values (SUVmax) obtained from 5 to 10. Conclusion: the radiopharmaceutical ⁶⁸Ga-PSMA I&T produced by the automatic synthesis module iQS-TS in the Nuclear Medicine Department at 108 Military Central Hospital had no single dose toxicity in the mice model. ⁶⁸Ga-PSMA I&T PET/CT images were consistent with the biological characteristics of animals and the pharmacodynamic of the radiopharmaceutical.