Article Sidebar
Views PDF: 77
SOME FEATURES OF RECONSTRUCTING CORTICO-CEREBELLAR TRACT BY USING DIFFUSION TENSOR IMAGING IN VIETNAMESE ALZNEIMER PATIENTS
Main Article Content
Abstract
Objectives: to evaluate some characteristics of the cortico-cerebellar tracts by Diffusion tensor imaging (DTI) in Vietnamese Alzheimer patients (AD). Methods: cross-sectional study, conducted on 32 people with AD, compared with 30 normal subjects (NS). Results: NS group: The mean (± SD) number and length of fibers, voxel, FA and ADC in the cortico – cerebellar on both sides (right and left): 580.73±256.86 fibers and 582.16± 256, 49 fibers; 131.15±9.15 mm and 125.15±9.22 mm; 1130.63±264.22 voxels and 1114.60±258.82 voxels; 0.46±0.02 and 0.46±0.01; 0.84±0.05 and 0.84±0.05. In particular, the number of fibers, number of voxels, FA and ADC are not statistically significant: p>0.05. The left fiber length is greater than the right with statistical significance: p=0.006. AD group: The mean (± SD) number and length of fibers, voxel, FA and ADC in the cortico – cerebellar on both sides (right and left): 390.90±275.37 fibers and 326.90±222.49 fibers; 106.22±23.89 mm and 113.67±25.21 mm; 899.56±355.79 voxels and 845.78±348.66 voxels; 0.45±0.03 and 0.46±0.03; 0.78±0.10 and 0.77±0.10; no significant difference in both side: p>0.05. Conclusion: the results suggest that microstructure changes in cortico-cerebellar tracts in Vietnamese Alzheimer patients.
Article Details
Keywords
Diffusion tensor imaging, cortico-cerebellar tract, Alzheimer
References
2. Vũ Hải Đăng, Lương Quốc Chính, Trần Quang Lục và CS. Đánh giá tổn thương sợi trục và dự đoán phục hồi chức năng vận động ở NB nhồi máu não cấp trên lều. Vietnam Medical Journal. 2022; 519:126-130.
3. Nguyễn Văn Điều. Nghiên cứu hình thái bó vỏ tuỷ trong não người Việt trưởng thành trên cộng hưởng từ sức căng khuếch tán (DTI). Luận văn thạc sỹ y học. Học viện Quân y. 2019.
4. Tomasch J. The numerical capacity of the human cortico-pontocerebellar system. Brain Res. 1969; 13(3):476-484.
5. Braak H. and E. Braak. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging. 1997; 18(4):351-357.
6. Bernard BL, et al. Correlation between caregiver reports of physical function and performance-based measures in a cohort of older adults with alzheimer disease. Alzheimer Dis Assoc Disord. 2016; 30(2):169-174.
7. Tào Thị Hoa, Trần Công Thắng. Đánh giá chức năng người bệnh Alzheimer bằng thang điểm FAST phân độ chức năng theo giai đoạn bệnh. Tạp chí Y học Thành phố Hồ Chí Minh. 2021; 25(2):41-46.
8. Mielke MM, P Vemuri, and WA Rocca. Clinical epidemiology of Alzheimer's disease: Assessing sex and gender differences. Clin Epidemiol. 2014; 6:37-48.
9. Kitamura K, et al. Diffusion tensor imaging of the cortico-ponto-cerebellar pathway in patients with adult-onset ataxic neurodegenerative disease. Neuroradiology. 2008; 50(4):285-292.
10. Kim Y, et al. Laterality of cerebellar afferent and efferent pathways in a healthy right-handed population: A diffusion tensor imaging study. J Neurosci Res. 2019; 97(5):582-596.