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Date Published: 21/06/2024
Abstract Views: 94
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DOI: https://doi.org/10.56535/jmpm.v49i5.746
Issue
Vol. 49 No. 5 (2024): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 5 - 2024
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Articles
How to Cite
Trương, Q. K., Nguyễn, T. B. H., Hoàng, P. K., Vũ, T. M. T., Phan, B. N., Nguyễn, V. C., Nguyễn, T. T. H., Hoàng, X. S., Lê, V. T., & Phạm, Q. T. (2024). VMMU75_Characteristics of BK Virus Load and Role in Predicting BK Virus-Associated Nephrology in Patients Post Kidney Transplantation_Truong Quy Kien. Journal of Military Pharmaco-medicine, 49(5), 77-86. https://doi.org/10.56535/jmpm.v49i5.746

VMMU75_Characteristics of BK Virus Load and Role in Predicting BK Virus-Associated Nephrology in Patients Post Kidney Transplantation_Truong Quy Kien

Quý Kiên Trương1, , Thị Bích Hằng Nguyễn2, Phúc Khăm Hoàng2, Thị Minh Thu Vũ2, Bá Nghĩa Phan2, Văn Cường Nguyễn3, Thị Thu Hà Nguyễn2, Xuân Sử Hoàng4, Việt Thắng Lê2, Quốc Toản Phạm2
1 Bệnh viện Quân 103
2 Bệnh viện Quân y 103, Học viện Quân y
3 Bệnh viện Trung ương Quân đội 108
4 Học viện Quân y

Main Article Content

Abstract

ABSTRACT


Objective: The study aimed to analyze the load characteristics of the BK virus in serum and urine and its role in predicting BK virus-associated nephrology in patients after kidney transplantation.


Subjects and Methods: 360 kidney transplant patients at Military Hospital 103 were included in a prospective cross-sectional study. Realtime-PCR was used to measure BK viral load in serum and urine samples. Patients who met the biopsy criteria underwent the procedure according to the protocol.


Results: The study found that 56.7% of kidney transplant patients had BK virus infection, with 3.1% developing BK virus-associated nephropathy. BK virus infection was most prevalent between 3-6 months post-transplantation. A BK virus load in serum was exceeding 1.3. 104 copies/mL predicted BK virus-associated nephropathy with 81.8% sensitivity and 87.1% specificity. In urine, a BK virus load exceeds 1.5. 106 copies/mL predicted BK virus-associated nephropathy with 90.9% sensitivity and 67.9% specificity. BK virus load in serum was a better predictor than in urine.


Conclusion: BK virus load plays a role in predicting BK virus-associated nephrology with a cutoff of 1.3. 104copies/mL in serum and 1.5 .106 copies/mL in urine.


Key words: Realtime- PCR, BK virus, Kidney transpalntation

Article Details

Keywords

Realtime-PCR, Virus BK, Kidney transplantation

References

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