MOLECULAR BIOMARKERS IN CANCER
Main Article Content
Abstract
Molecular cancer biomarkers are are molecules that can be measured and analyzed to gain information about the presence, progression, or response to treatment of a specific type of cancer. These molecules can be can be detected from various sources, including tissues and different body fluids such as blood, urine, stool, and others. The identification of cancer biomarkers plays a crucial role in various aspects of cancer research and clinical practice, including the detection, diagnosis, monitoring, and development of treatments for cancer. Biomarkers of cancer are widely used in clinical practice. Currently, with advancements in science and technology, methods for detecting molecular markers of cancer are continuously evolving and becoming more modern and effective. Understanding cancer molecular biomarkers is crucial for the development of new biomarkers with improved sensitivity, specificity, and clinical value.
Article Details
Keywords
Cancer biomarkers, predictive biomarkers, screening biomarkers, prognostic biomarkers.
References
2. Casaubon JT, Kashyap S, Regan JP. BRCA1 and BRCA2 mutations. in: StatPearls. StatPearls Publishing; 2023. Accessed January 16, 2024. http://www.ncbi.nlm.nih.gov/books/NBK470239/.
3. Wang S, Wu W. Chapter 5 - DNA methylation alterations in human cancers. In: Tollefsbol TO, ed. Epigenetics in Human Disease (Second Edition). Vol 6. Translational Epigenetics. Academic Press; 2018:109-139. DOI: 10.1016/B978-0-12-812215-0.00005-4.
4. Vasilatou D, Papageorgiou S, Pappa V, Papageorgiou E, Dervenoulas J. The role of microRNAs in normal and malignant hematopoiesis. Eur J Haematol. 2010; 84(1):1-16. DOI: 10.1111/j.1600-0609.2009.01348.x.
5. Liang G, Liu Z, Tan L, Su AN, Jiang WG, Gong C. HIF1α-associated circDENND4C promotes proliferation of breast cancer cells in hypoxic environment. Anticancer Res. 2017; 37(8):4337-4343. DOI: 10.21873/ anticanres.11827.
6. Han D, Li J, Wang H, et al. Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatol Baltim Md. 2017; 66(4):1151-1164. DOI: 10.1002/hep.29270.
7. Yao Z, Luo J, Hu K, et al. ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways. Mol Oncol. 2017; 11(4):422-437. DOI: 10.1002/1878-0261.12045.
8. Huang XY, Huang ZL, Xu YH, et al. Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. Sci Rep. 2017; 7(1):5428. DOI: 10.1038/s41598-017-05432-8.
9. Ding L, Zheng Q, Lin Y, et al. Exosome-derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase-3-dependent cleavage. Clin Transl Med. 2023; 13(1):e1156. DOI: 10.1002/ctm2.1156.
10. Grambergs R, Mondal K, Mandal N. Inflammatory ocular diseases and sphingolipid signaling. Adv Exp Med Biol. 2019; 1159:139-152. DOI: 10.1007/978-3-030-21162-2_8.