RELATIONSHIP BETWEEN ANEMIA AND SOME CLINICAL FEATURES IN PATIENTS AFTER KIDNEY TRANSPLANTATION AT MILITARY HOSPITAL 103

Anh Trung Hoàng1, , Thị Miến Hoàng2, Thị Hiền Mai3, Hữu Dũng Nguyễn4, Việt Thắng Lê5
1 Bệnh viện Bạch Mai
2 Khoa Nội chung, Viện Y học Phòng không - Không quân
3 Khoa Nội tổng hợp, Bệnh viện Đa khoa Tâm Anh
4 Trung tâm Thận tiết niệu và lọc máu, Bệnh viện Bạch Mai
5 Bộ môn - Khoa Thận - Lọc máu, Bệnh viện Quân y 103, Học viện Quân y

Main Article Content

Abstract

(1) Objective: This study aims to delineate the characteristics of anemia in patients beyond 12 months post-kidney transplant under treatment surveillance at Military Hospital 103 and analyze the correlation between the degree of anemia and specific clinical characteristics in these individuals. (2) Method: A cross-sectional descriptive study involving 123 post-kidney transplant patients, monitored for over 12 months from October 2022 to May 2023. (3) Results: The mean age of participants was 41.93 ± 11.42 years, with a male/female ratio of 1.2/1. Notably, 13.8% and 25.2% of patients were transplanted preemptively before dialysis and maintained follow-up for more than 10 years post-transplant, respectively. The majority of patients (52.8%) exhibited mild anemia, characterized by normal-sized red blood cells (72.4%) and isochromic features (54.5%). The degree of anemia demonstrated statistically significant differences among BMI groups and blood pressure control (p<0.05). A low BMI below 18.5 emerged as an independent risk factor associated with the degree of anemia in patients after kidney transplantation, with an odds ratio of 3.633 and p < 0.05. (4) Conclusion: Anemia remains a prevalent issue in post-kidney transplant patients, primarily presenting as mild in severity, characterized by normochromic, normocytic features. The study highlights the association between undercontrolled hypertension and post-transplant anemia, emphasizing that a low BMI below 18.5 independently contributes as a significant risk factor for severe anemia.

Article Details

References

1. Nguyễn Thị Thanh Huyền, Mai Thị Hiền, Đỗ Gia Tuyển. Thực trạng thiếu máu và một số yếu tố liên quan trên bệnh nhân sau ghép thận. Tạp chí Y học Việt Nam. 2021; 509:385-393.
2. Hội ghép tạng Việt nam. Hướng dẫn ghép thận Việt nam. Nhà xuất bản Y học. 2017; 2:283-293.
3. WHO G. WHO methods and data sources for global burden of disease estimates 2000-2011. Geneva: Department of Health Statistics and Information Systems. 2013.
4. Kasiske BL, et al. Recommendations for the outpatient surveillance of renal transplant recipients. American Society of Transplantation. J Am Soc Nephrol. 2000; 11(15):S1-86.
5. Molnar MZ, Mucsi I, Macdougall IC, et al. Prevalence and management of anaemia in renal transplant recipients: data from ten European centres. Nephron Clinical Practice. 2011; 117(2):c127-c134.
6. Schechter A, Gafter-Gvili A, Shepshelovich D, et al. Post renal transplant anemia: Severity, causes and their association with graft and patient survival. BMC Nephrology. 2019; 220(1): 1-11.
7. Rosales Morales KB, Pérez RE, Cancino López JD, et al. Anemia and erythrocytes: Behavior and prevalence 1 year after kidney transplant. Transplant Proc. 2020; 252(4):1169-1172.
8. Beshara S, Birgegard G, Goch J, et al. Assessment of erythropoiesis following renal transplantation. Eur J Haematol. 1997; 58(3):167-173.
9. Taber DJ, Meadows HB, Pilch NA, et al. Pre-existing diabetes significantly increases the risk of graft failure and mortality following renal transplantation. Clin Transplant. 2013; 27(2):2.
10. Kim CS, Oh TR, Suh SH, et al. Uncontrolled hypertension is associated with increased risk of graft failure in kidney transplant recipients: A nationwide population-based study. Front. Cardiovasc. Med. 2023; 10:1185001.
11. Winkelmayer WC, Kewalramani R, Rutstein M, et al. Pharmacoepidemiology of anemia in kidney transplant recipients. J Am Soc Nephrol. 2004; 15:1347-1352.
12. Shiferaw WS, TY Akalu, and YA Aynalem. Risk factors for anemia in patients with chronic renal failure: A systematic review and meta-analysis. Ethiop J Health Sci. 2020; 30(5):829-842.
13. Gafter-Gvili A, et al. Posttransplantation anemia in kidney transplant recipients: A retrospective cohort study. Medicine (Baltimore). 2017; 96(32):e7735.
14. Friend P, Russ G, Oberbauer R, et al. Incidence of anemia in sirolimus-treated renal transplant recipients: The importance of preserving renal function. Transpl Int. 2007; 220:754-760.