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NGHIÊN CỨU SỰ BỘC LỘ DẤU ẤN PD-L1 Ở BỆNH NHÂN UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ
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Abstract
Objective: to investigate the prevalence of PD-L1 expression and its correlation with histopathological subtypes and EGFR gene mutation characteristics in patients with non-small cell lung cancer (NSCLC). Subjects and methods: a cross-sectional study conducted on 138 patients diagnosed with NSCLC at 103 Military Hospital from June 2021 to June 2023. Histopathological subtypes, EGFR gene mutation, and the PD-L1 expression were determined based on the patient's biopsy samples. Prevalence of PD-L1 expression and its correlation with the collected factors were archived. Results: 48.5% of cases were positive for PD-L1, including 18,8% cases with tumor proportion score (TPS) ranging from 1% to 49% and 29.7% cases with TPS≥50. The expression of PD-L1 had no correlation with age, gender, and histopathological subtypes but was significantly associated with EGFR status: tumor cells with PD-L1 positive had a low rate of EGFR gene mutations. Conclusion: PD-L1 expression had a significant correlation with wild-type EGFR
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Keywords
PD-L1, Non-small cell lung cancer (NSCLC), EGFR mutation
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