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Date Published: 28/02/2024
Abstract Views: 103
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DOI: https://doi.org/10.56535/jmpm.v49i2.689
Issue
Vol. 49 No. 2 (2024): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 2 - 2024
Section
Articles
How to Cite
Đỗ , Q. C., & Bùi, K. C. (2024). CONTROLLING PROLIFERATION OF COLON CANCER CELLS THROUGH INHIBITION OF P97 - A PROTEIN INVOLVED IN DNA DAMAGE REPAIR. Journal of Military Pharmaco-medicine, 49(2), 70-79. https://doi.org/10.56535/jmpm.v49i2.689

CONTROLLING PROLIFERATION OF COLON CANCER CELLS THROUGH INHIBITION OF P97 - A PROTEIN INVOLVED IN DNA DAMAGE REPAIR

Quỳnh Chi Đỗ 1, Khắc Cường Bùi2,
1 Laboratory Animal Research Center, Vietnam Military Medical University
2 Trung tâm nghiên cứu động vật thực nghiệm, Học viện quân y

Main Article Content

Abstract

Objectives: DNA damage repair plays an important role in cell survival and development. Inhibition of DNA damage repair is the target of several therapeutic treatments. This study was conducted to evaluate the inhibitory effect of CB5083 on colon cancer cells, a specific inhibitor of p97 - a protein involved in the DNA damage repair. Methods: The study used CB5083, a specific p97 inhibitor, and the colon cancer cell line HCT116. Experimental assays were used including cell proliferation assay, cell migration assay, cell cycle assay by flowcytometry. Results: CB5083 inhibited HCT116 cell proliferation in vitro. CB5083 also affects cell migration and cell distribution at different phases of the cell cycle. Conclusion: CB5083, a specific inhibitor of p97 – a protein involved in DNA damage repair, has a proliferative inhibition on colon cancer cells in vitro.

Article Details

Keywords

DNA damage repair, colon cancer, p97

References

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