NGHIÊN CỨU CHỈ SỐ GAN NHIỄM MỠ Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TÝP 2
Main Article Content
Abstract
FATTY LIVER INDEX (FLI) IN PATIENTS WITH TYPE 2 DIABETES
Objective: To investigate the Fatty liver index (FLI) and its relationship with some clinical and paraclinical characteristics in patients with type 2 diabetes. Subjects and methods: a cross-sectional and descriptive study on 94 patients with type 2 diabetes treated at Hospital 103. Results: The median of FLI was 23.76. The FLI cut-off to diagnose NAFLD was 20.87. Of the 94 patients with type 2 diabetes, there were 10 patients with FLI >60, accounting for 10.5%. The percentage of patients with FLI <30 was 53 patients, accounting for 55.8%, and there were 31 patients with FLI < 30. 32.6% of patients are suspected of having fatty liver. The FLI values in the grades 2 and 3 NAFLD were significantly higher than those in the grade 1 and normal groups. In univariate regression, FLI positively correlates with BMI and insulin resistance index (r = 0.756 and 0.483, respectively). Conclusion: The median value of FLI is 23.76. The threshold for diagnosing GNM using FLI in type 2 diabetes mellitus was 20.87. FLI values relate to the grades of fatty liver on ultrasound images. FLI values correlate positively with insulin resistance level and BMI.
Article Details
Keywords
Đái tháo đường týp 2, Gan nhiễm mỡ, Chỉ số gan nhiễm mỡ, Kháng insulin
References
2. Bedogni G, Bellentani S, Miglioli L et al. The fatty liver index: A simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol. 2006; 6:33.
3. Browning JD, Szczepaniak LS, Dobbins R et al. Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology. 2004; 40(6):1387-1395.
4. Chung TH, Kim JK, Kim JH et al. Fatty liver index as a simple and useful predictor for 10-year cardiovascular disease risks determined by Framingham risk score in the General Korean Population. J Gastrointestin Liver Dis. 2021; 30(2):221-226.
5. Dhananjay Yadav, Eunhee Choi, Song Vogue Ahn et al. Fatty liver index as a simple predictor of incident diabetes from the KoGES-ARIRANG study. Medicine (Baltimore). 2016; 95(31):e4447.
6. Elisa F, Shelby S, Samuel K. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic and clinical implications. Hepatology. 2010; 51(2):679-689.
7. Golo Petzold. Role of Ultrasound Methods for the Assessment of NAFLD. J Clin Med. 2022; 11(15):4581.
8. Gisela, Silvia FB, Fernando P. Triglycerides and glucose index: A useful indicator of insulin resistance. Endocrinol Nutr. 2014; 61(10):533-540.
9. Meyer C, Dostou JM, Welle SL et al. Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis. Am J Physiol Endocrinol Metab. 2002; 282(2):E419-E427.
10. Sumida Y, Nakajima A, Itoh Y. Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol. 2014; 20(2):475-485.
11. Zhao-Yan Jiang, Chen-Ying Xu, Xian-Xing Chang et al. Fatty liver index correlates with non-alcoholic fatty liver disease, but not with newly diagnosed coronary artery atherosclerotic disease in Chinese patients. BMC Gastroenterol. 2013; 13(1):110.