ĐÁNH GIÁ MỐI LIÊN QUAN CỦA NỒNG ĐỘ cf DNA-EBV HUYẾT TƯƠNG TRƯỚC ĐIỀU TRỊ VỚI ĐÁP ỨNG ĐIỀU TRỊ SAU HÓA CHẤT DẪN ĐƯỜNG TRÊN BỆNH NHÂN UNG THƯ BIỂU MÔ VÒM MŨI HỌNG GIAI ĐOẠN III-IVa

Abstract

Objectives: Assessment correlation between pre-treatment cf EBV – DNA level and response of treatment after induction chemotherapy of nasopharyngeal carcinoma stage III – IVa. Subjects and method: A descriptive, prospective, longitudinal study on 88 patients’ nasopharyngeal carcinoma stage III - IVa at National Cancer Hospital from August 2021 to November 2022.  Results: After induction chemotherapy, 90,0% of patients had a partial response of treatment at the primary tumor and the lymph nodes, which was 90,9% and 98,9% of patients was partial response. The highest pretreatment plasma cf EBV – DNA level was observed in the group >1500 copy/ml in all stages T, N and TNM stage, in which the highest level was at T3 (43995,67 copies/ml) and the lowest at T1 (9439,20 copy/ml). The highest level at N0 was 67178,50 copy/ml and the lowest level at N3 was 22291,02 copy/ml. The average level at stage III is 30887,75 copy/ml, and at stage IVa was 36310,71copy/ml, of all patients in the study was 33670,20 copy/ml. Plasma cf EBV – DNA level > 1500 copy/ml were 85,2% in total and at stage III was 85,6%, at stage IVa was 84,8%. The plasma cf EBV – DNA level pretreatment was proportional to the response to treatment at the primary tumor, lymph nodes and to the overall response of treatment after the induction chemotherapy with correlation coefficients were 0,174; 0,157 and 0,040, respectively. Conclusions: After induction chemotherapy, the mainly response of treatment is partial response. The plasma cf DNA-EBV level of the patients was mainly in the group >1500 copy/ml and the higher plasma cf DNA-EBV level pretreatment, the better the response of treatment after the induction chemotherapy.